Mouse Cingulin Monoclonal Antibody | anti-CGN antibody
Cingulin antibody
Reactivity
Bovine, Frog, Human, Mouse
Applications
Immunohistochemistry, Western Blot
Purity
Culture supernatant
Synonyms
Cingulin; Monoclonal Antibody; Cingulin antibody; Monoclonal Cingulin; Anti-Cingulin; anti-CGN antibody
Host
Mouse
Reactivity
Bovine, Frog, Human, Mouse
Clonality
Monoclonal
Isotype
IgM
Clone Number
139.3.4
Purity/Purification
Culture supernatant
Form/Format
Hybridoma culture supernatant.
Concentration
5.0 ml per vial (varies by lot)
Sequence Length
1203
Applicable Applications for anti-CGN antibody
Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)
Biological Significance
Cingulin is a protein that in humans is encoded by the CGN gene. Cingulin is specifically localized at tight junctions in epithelial cells, unlike ZO-1, which is also detected at adherens-type junctions in non-epithelial cells. During early Xenopus embryo development, cingulin is detected at a cortical localization, and then accumulates at apical junctions, unlike ZO-1 and other junctional proteins, that are targeted to the new regions of cell-cell contact via the lateral domain.
Cross-Reactivity
Bovine, frog, human, mouse
Immunogen
Cingulin antibody was raised in mouse using a synthetic peptide corresponding to residues 4-24 of cingulin as the immunogen.
Preparation and Storage
Store at 4 degree C.
Related Product Information for anti-CGN antibody
Mouse monoclonal Cingulin antibody
Product Categories/Family for anti-CGN antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
87,047 Da
NCBI Official Full Name
cingulin
NCBI Official Synonym Full Names
cingulin
NCBI Official Symbol
CGN
NCBI Protein Information
cingulin
UniProt Protein Name
Cingulin
Protein Family
UniProt Gene Name
CGN
UniProt Synonym Gene Names
KIAA1319
UniProt Entry Name
CING_HUMAN
Uniprot Description
CGN: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the cingulin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: tight junction; cell junction; myosin complex
Molecular Function: protein binding; microtubule binding; motor activity; actin binding
Biological Process: metabolic process; transforming growth factor beta receptor signaling pathway; microtubule cytoskeleton organization and biogenesis
Research Articles on CGN
Similar Products
Product Notes
The CGN cgn (Catalog #AAA531532) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Cingulin antibody reacts with Bovine, Frog, Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Cingulin can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB). Researchers should empirically determine the suitability of the CGN cgn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cingulin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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