Rabbit APEX2 Polyclonal Antibody | anti-APEX2 antibody
APEX2 Antibody
Gene Names
APEX2; APE2; XTH2; ZGRF2; APEXL2
Applications
Western Blot, Immunohistochemistry
Purity
Affinity Chromatography
Synonyms
APEX2; Polyclonal Antibody; APEX2 Antibody; Affinity Purified Rabbit Polyclonal APEX2 Antibody; Polyclonal APEX2 antibody; Anti-APEX2 antibody; APEX-2 antibody; APEX-2; APEX 2; Apurinic/apyrimidinic endonuclease like-2 antibody; APEX 2 antibody; anti-APEX2 antibody
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Chromatography
Form/Format
Lyophilized Form
Sequence Length
43
Applicable Applications for anti-APEX2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Immunogen
APEX2 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human APEX2, identical to the related rat and Rabbit sequences, as the immunogen
Preparation and Storage
Store at 4 degree C for short term storage. For long term storage aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.
Related Product Information for anti-APEX2 antibody
APEX2, also called apurinic/apyrimidinic endonuclease like-2, is a member of the apurinic/apyrimidinic (AP) family of endonucleases that initiate the repair of AP sites formed by spontaneous hydrolysis of the N-glycosylic bond, mutagen-induced base release, or damaged-base excision by a DNA repair glycosylase. RT-PCR detected APEX2 expression in HeLa cells, Jurkat cells, and human kidney, brain and fetal brain tissue.The APEX2 gene contains 6 exons. The APEX2 gene is mapped to chromosome Xp11.21. APEX2 participates in both nuclear and mitochondrial base excision repair (BER). APEX2 displayed weaker AP site-specific and 3-prime nuclease activities compared to APEX1. APEX2 plays a role in processing 3-prime-damaged termini or 3-prime-mismatched nucleotides.
Product Categories/Family for anti-APEX2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
alternative protein APEX2
NCBI Official Synonym Full Names
apurinic/apyrimidinic endodeoxyribonuclease 2
NCBI Official Symbol
APEX2
NCBI Official Synonym Symbols
APE2; XTH2; ZGRF2; APEXL2
NCBI Protein Information
DNA-(apurinic or apyrimidinic site) lyase 2
Protein Family
NCBI Description
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Research Articles on APEX2
Similar Products
Product Notes
The APEX2 (Catalog #AAA5312807) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's APEX2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the APEX2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APEX2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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