Rabbit CLOCK Polyclonal Antibody | anti-CLOCK antibody

CLOCK Antibody

Cat. Num. AAA5311531

• Gene Names: CLOCK; KAT13D; bHLHe8
• Applications: Western Blot
• Purity: Affinity Chromatography
• Synonyms: CLOCK; Polyclonal Antibody; CLOCK Antibody; Rabbit Polyclonal CLOCK Antibody; Polyclonal CLOCK antibody; anti-CLOCK antibody; Circadian Locomoter Output Cycles Kaput antibody; clock homolog antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Chromatography
• Form/Format: Supplied in PBS buffer, pH 7.2, containing 30% Glycerol, 0.5% BSA, and 0.01% Thimerosal
• Concentration: 500 ug/ml (varies by lot)
• Sequence Length: 845

• Applicable Applications for anti-CLOCK antibody: Western Blot (WB)
• Application Notes: WB: 0.5-4 ug/ml
• Immunogen: CLOCK antibody was raised in Rabbit using synthetic peptide surrounding amino acid 842of mouse Clock as the immunogen.
• Cross-Reactivity: Human, Mouse, Rat
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of Clock expression in Jurkat cell lysate (Lane 1 & 2).)

Related Product Information for anti-CLOCK antibody

Clock is a basic helix-loop helix transcription factor that regulates circadian rhythms and sleep cycles. Clock contain a DNA-binding domain, a protein dimerization domain that heterodimerizes with BMAL1 and a glutamine-rich C terminus region. Clock dimerization with BMAL helps regulate nuclear translocation and binding of Clock to the E box elements stimulates circadian genes transcription.

Product Categories/Family for anti-CLOCK antibody

DNA & RNA

NCBI and Uniprot Product Information

• NCBI GI #: 6478192
• NCBI GeneID: 9575
• NCBI Official Full Name: clock, partial
• NCBI Official Synonym Full Names: clock circadian regulator
• NCBI Official Symbol: CLOCK
• NCBI Official Synonym Symbols: KAT13D; bHLHe8
• NCBI Protein Information: circadian locomoter output cycles protein kaput
• Protein Family: Clock-controlled protein

NCBI Description

The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]