ApoA1 native protein

ApoA1 protein

Cat. Num. AAA5310769

• Gene Names: APOA1; apo(a)
• Purity: > 96% pure
• Synonyms: ApoA1; ApoA1 protein; Purified native Human ApoA1 protein; Apolipoprotein A-I protein; Apolipoprotein A1 protein; ApoA I protein; ApoA 1; ApoA-1; ApoA-1 protein; Apo AI protein; ApoA 1 protein; ApoA1 native protein

• Host: Human
• Purity/Purification: > 96% pure
• Form/Format: Frozen liquid,0.2 micron filtered solution in 10 mM ammonium bicarbonate, pH 7.4.
• Concentration: > 1.0 mg/mL (BCA) (varies by lot)
• Sequence Length: 14

• Source Note: Human Plasma
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Upon receipt store at-20 degree C.

Related Product Information for ApoA1 native protein

Apo-AI comprises ~70% of the protein moiety in HDL. It is a single polypeptide chain consisting of 245 amino acids with glutamic acid as the C-terminal residue and aspartic acid as the N-terminal residue. Apo-AI levels in normal plasma are 90-130 mg/dL.

Product Categories/Family for ApoA1 native protein

Cardiac Markers

NCBI and Uniprot Product Information

• NCBI GI #: 553183
• NCBI GeneID: 335
• Molecular Weight: 28.3 kDa
• NCBI Official Full Name: APOA1, partial
• NCBI Official Synonym Full Names: apolipoprotein A1
• NCBI Official Symbol: APOA1
• NCBI Official Synonym Symbols: apo(a)
• NCBI Protein Information: apolipoprotein A-I
• UniProt Protein Name: Apolipoprotein A-I
• Protein Family: Apolipoprotein
• UniProt Gene Name: APOA1
• UniProt Synonym Gene Names: Apo-AI; ApoA-I; ProapoA-I

NCBI Description

This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]

Uniprot Description

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.