Mouse anti-Human IL-4 IL4 Monoclonal Antibody | anti-IL4 antibody
IL4 antibody
Reactivity
Human IL-4
Applications
ELISA, Western Blot
Synonyms
IL4; Monoclonal Antibody; IL4 antibody; Monoclonal IL4; Anti-IL4; Interleukin 4; B cell stimulating factor; BSF-1; IL-4; IL 4; BCGF; BCDF; anti-IL4 antibody
Host
Mouse
Reactivity
Human IL-4
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
M6110641
Specificity
Human IL-4
Form/Format
Purified murine ascites, supplied in PBS buffer, pH 7.2 with no preservatives added.
Sequence Length
133
Applicable Applications for anti-IL4 antibody
ELISA (EIA), Inhibition, Western Blot (WB)
Application Notes
ELISA: 0.5-1 ug/ml
Inhibition: 6.0-8.5 ug/ml
Inhibition: 6.0-8.5 ug/ml
Biological Significance
IL4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL4, IL5, IL6, IL10, and IL13, which favor a humoral immune response. Another dominant function of IL4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL4 production by Th2 cells has been associated with elevated IgE production and allergy.
Immunogen
IL4 antibody was raised in mouse using recombinant human IL-4 as the immunogen.
Preparation and Storage
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
Related Product Information for anti-IL4 antibody
Mouse monoclonal IL4 antibody
Product Categories/Family for anti-IL4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
14.0 kDa (predicted detection band MW)
NCBI Official Full Name
interleukin-4
NCBI Official Symbol
IL4
NCBI Protein Information
interleukin-4
UniProt Protein Name
Interleukin-4
Protein Family
UniProt Gene Name
IL4
UniProt Synonym Gene Names
IL-4; BSF-1
UniProt Entry Name
IL4_PIG
Uniprot Description
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.
Research Articles on IL4
Similar Products
Product Notes
The IL4 il4 (Catalog #AAA530999) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The IL4 antibody reacts with Human IL-4 and may cross-react with other species as described in the data sheet. AAA Biotech's IL4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Inhibition, Western Blot (WB). ELISA: 0.5-1 ug/ml Inhibition: 6.0-8.5 ug/ml. Researchers should empirically determine the suitability of the IL4 il4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL4, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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