Mouse anti-Human MALT1 Monoclonal Antibody | anti-MALT1 antibody

MALT1 antibody

Cat. Num. AAA5309287

• Gene Names: MALT1; MLT; MLT1; IMD12; PCASP1
• Reactivity: Human
• Applications: Functional Assay
• Purity: Purified by affinity chromatography.
• Synonyms: MALT1; Monoclonal Antibody; MALT1 antibody; Mouse monoclonal MALT1 antibody; Monoclonal MALT1 antibody; Anti-MALT1 antibody; MALT-1 antibody; MALT-1; MALT 1; MALT 1 antibody; mucosa associated lymphoid tissue lymphoma translocation gene antibody; anti-MALT1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 50
• Specificity: Human
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.
• Sequence Length: 813

• Applicable Applications for anti-MALT1 antibody: Functional Assay
• Preparation and Storage: Store at 2-8 degree C. Do not freeze. Protect from light.

Immunohistochemistry (IHC)

(Immunohistochemistry on formalin-fixed paraffin embedded human tonsil tissue with citrate buffer antigen retrieval, using MALT1 antibody (10 ug/ml) (right) or Mouse IgG1 kappa Isotype Control antibody (left) detected with Anti-Mouse Ig Biotin and DAB visualization. Nuclei are counterstained with hematoxylin.)

Related Product Information for anti-MALT1 antibody

The monoclonal antibody 50 recognizes human MALT1. MALT1 is a 91 kDa paracaspase that contains a death domain, two Ig-like domains and a C terminal caspase-like domain. Like other caspases, it cleaves substrates after an arginine residue. Expression is found in the cytoplasm of B and T cells. Within B cell follicles, MALT1 expression is highly expressed in centroblasts, followed by centrocytes and weakly expressed in the mantle zone. The interaction of MALT1 and Bcl10 occurs through Ig-like domains resulting in oligomerization and activation of the caspase-like domain. This also directly results in NFkappa B activation thereby playing a role in B cell maturation and activation.Rearrangements of the MALT1 gene found in t and t are the most frequent structural chromosomal abnormalities in MALT lymphomas. These translocations lead to fusions of API2 MALT1 and IGH MALT1 respectively. An additional translocation between MALT1 and MAP4 has also been identified in DLBCL. The antibody 50 reacts with the C terminal domain of MALT1, which allows for the detection of endogenous MALT1 as well as both identified fusion proteins resulting from translocation events.

Product Categories/Family for anti-MALT1 antibody

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 5706378
• NCBI GeneID: 10892
• Molecular Weight: 91,081 Da
• NCBI Official Full Name: MALT1
• NCBI Official Synonym Full Names: MALT1 paracaspase
• NCBI Official Symbol: MALT1
• NCBI Official Synonym Symbols: MLT; MLT1; IMD12; PCASP1
• NCBI Protein Information: mucosa-associated lymphoid tissue lymphoma translocation protein 1
• UniProt Protein Name: Mucosa-associated lymphoid tissue lymphoma translocation protein 1
• Protein Family: Mucosa-associated lymphoid tissue lymphoma translocation protein
• UniProt Gene Name: MALT1
• UniProt Synonym Gene Names: MLT

NCBI Description

This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018]

Uniprot Description

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation ().