GSTP1 recombinant protein

Purified recombinant GSTP1 protein

Cat. Num. AAA5308691

• Gene Names: GSTP1; PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22
• Applications: ELISA, SDS-Page, Western Blot
• Purity: > 90% pure
• Synonyms: GSTP1; Purified recombinant GSTP1 protein; GSTP1 protein; GSTP1 recombinant protein

• Host: Human
• Purity/Purification: > 90% pure
• Form/Format: Supplied in liquid form in 20mM Tris-Hcl, 0.5MNaCl, 10% glycerin (pH 8.0) and 200 mM Imidazole
• Sequence Length: 210

• Applicable Applications for GSTP1 recombinant protein: ELISA (EIA), SDS-PAGE, Western Blot (WB)
• Expression: E Coli
• Preparation and Storage: Store at 4 degree C in a working aliquot for 1 week. For long term storage, aliquot and freeze at -20 to -80 degree C, avoid repeat freeze/thaw cycles.

Product Categories/Family for GSTP1 recombinant protein

Proteases; Inhibitors; & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 4504183
• NCBI GeneID: 2950
• NCBI Accession #: NP_000843.1
• NCBI GenBank Nucleotide #: NM_000852.3
• UniProt Accession #: P09211; O00460; Q15690; Q5TZY3
• Molecular Weight: 23,356 Da
• NCBI Official Full Name: glutathione S-transferase P
• NCBI Official Synonym Full Names: glutathione S-transferase pi 1
• NCBI Official Symbol: GSTP1
• NCBI Official Synonym Symbols: PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22
• NCBI Protein Information: glutathione S-transferase P
• UniProt Protein Name: Glutathione S-transferase P
• Protein Family: Glutathione S-transferase
• UniProt Gene Name: GSTP1
• UniProt Synonym Gene Names: FAEES3; GST3

NCBI Description

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

Uniprot Description

GSTP1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Homodimer. Interacts with CDK5. Belongs to the GST superfamily. Pi family.

Protein type: EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: cytoplasm; cytosol; extracellular space; intracellular; mitochondrion; vesicle

Molecular Function: glutathione peroxidase activity; glutathione transferase activity; JUN kinase binding; kinase regulator activity; protein binding

Biological Process: central nervous system development; glutathione metabolic process; linoleic acid metabolic process; negative regulation of apoptosis; negative regulation of biosynthetic process; negative regulation of fibroblast proliferation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interleukin-1 beta production; negative regulation of JNK activity; negative regulation of MAP kinase activity; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of protein kinase activity; negative regulation of stress-activated MAPK cascade; negative regulation of tumor necrosis factor production; positive regulation of superoxide release; regulation of stress-activated MAPK cascade; response to reactive oxygen species; xenobiotic metabolic process