Mouse FADD Monoclonal Antibody | anti-FADD antibody

Mouse monoclonal FADD antibody

Cat. Num. AAA5306057

• Gene Names: FADD; GIG3; MORT1
• Applications: Immunofluorescence, Western Blot
• Purity: Purified by affinity chromatography
• Synonyms: FADD; Monoclonal Antibody; Mouse monoclonal FADD antibody; FADD antibody; anti-FADD antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: T1B
• Purity/Purification: Purified by affinity chromatography
• Form/Format: Supplied in PBS buffer containing 30% glycerol, 0.5% BSA and 0.01% thimerosal
• Concentration: 200 ug/ml (varies by lot)
• Sequence Length: 208

• Applicable Applications for anti-FADD antibody: Immunofluorescence (IF), Western Blot (WB)
• Application Notes: WB: 1-4 ug/ml
• Immunogen: FADD antibody was raised in Mouse using recombinant human FADD as the immunogen.
• Cross-Reactivity: Human, Mouse, Dog
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Product Categories/Family for anti-FADD antibody

Cell Cycle & Cell Death

NCBI and Uniprot Product Information

• NCBI GI #: 48145593
• NCBI GeneID: 8772
• UniProt Accession #: Q13158; Q14866; Q6IBR4
• Molecular Weight: 23,279 Da
• NCBI Official Full Name: FADD
• NCBI Official Synonym Full Names: Fas associated via death domain
• NCBI Official Symbol: FADD
• NCBI Official Synonym Symbols: GIG3; MORT1
• NCBI Protein Information: FAS-associated death domain protein
• UniProt Protein Name: FAS-associated death domain protein
• Protein Family: Fas-associated death domain protein
• UniProt Gene Name: FADD
• UniProt Synonym Gene Names: MORT1

NCBI Description

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

Uniprot Description

FADD: an adaptor molecule that mediates apoptosis. Recruited through its C-terminal death domain by Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TRAIL-receptor, participating in the death signaling initiated by these receptors. Interaction with the receptors unmasks the N-terminal effector domain of this protein, which recruits caspase-8, and thereby activates the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Protein type: Adaptor/scaffold; Apoptosis

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: CD95 death-inducing signaling complex; cytoplasm; cytosol; plasma membrane

Molecular Function: identical protein binding; protease binding; protein binding; tumor necrosis factor receptor superfamily binding

Biological Process: apoptosis; caspase activation; cell surface receptor linked signal transduction; defense response to virus; induction of apoptosis via death domain receptors; lymph node development; positive regulation of activated T cell proliferation; positive regulation of adaptive immune response; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon-gamma production; positive regulation of interleukin-8 production; positive regulation of macrophage differentiation; positive regulation of proteolysis; positive regulation of T cell mediated cytotoxicity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; spleen development; T cell differentiation in the thymus; T cell homeostasis; thymus development

Disease: Infections, Recurrent, With Encephalopathy, Hepatic Dysfunction, And Cardiovascular Malformations