Factor IX Plasma | F9 plasma

Factor IX Deficient Plasma

Cat. Num. AAA514011

• Gene Names: F9; FIX; P19; PTC; HEMB; THPH8; F9 p22
• Synonyms: Factor IX; Factor IX Deficient Plasma; F9 plasma

• Sequence Length: 17

• Presentation: Frozen Factor IX deficient plasma
• Preperation and Handling: Thaw 1mL vials in 37°C for 5 minutes; for bulk volumes , thawing time will be dependent on bottle size.
• Assay: FIX (activity); Lot No: DP9-0197 ; <0.01 U/mL
• Preparation and Storage: Plasma is shipped frozen and should be stored below -60°C. Product is stable until date stated on vial label when stored at -60°C. Once thawed , plasma is stable for 4 hours at 2°C-8°C in original vial.

Related Product Information for F9 plasma

Pooled normal citrated human plasma depleted of Factor IX using antibodiesdirected to Factor IX immobilized on agrose beads. Plasma contains 20 mM HEPES.

Product Categories/Family for F9 plasma

Neutralizing Antibodies & Control IgG

NCBI and Uniprot Product Information

• NCBI GI #: 4469253
• NCBI GeneID: 2158
• Molecular Weight: 47,618 Da
• NCBI Official Full Name: factor IX, partial
• NCBI Official Synonym Full Names: coagulation factor IX
• NCBI Official Symbol: F9
• NCBI Official Synonym Symbols: FIX; P19; PTC; HEMB; THPH8; F9 p22
• NCBI Protein Information: coagulation factor IX
• UniProt Protein Name: Coagulation factor IX
• Protein Family: Coagulation factor
• UniProt Gene Name: F9
• UniProt Synonym Gene Names: PTC

NCBI Description

This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Sep 2015]

Uniprot Description

F9: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB); also known as Christmas disease. Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide. Defects in F9 are the cause of thrombophilia due to factor IX defect (THPH8). A hemostatic disorder characterized by a tendency to thrombosis. Belongs to the peptidase S1 family.

Protein type: EC 3.4.21.22; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xq27.1

Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen; plasma membrane

Molecular Function: calcium ion binding; endopeptidase activity

Biological Process: blood coagulation; blood coagulation, extrinsic pathway; blood coagulation, intrinsic pathway; ER to Golgi vesicle-mediated transport; peptidyl-glutamic acid carboxylation; proteolysis; signal peptide processing; zymogen activation

Disease: Coumarin Resistance; Hemophilia B; Thrombophilia, X-linked, Due To Factor Ix Defect