OX40L recombinant antibody
Anti-OX40L [R4930 (Oxelumab)]
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Description
TNFSF4: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance. Belongs to the tumor necrosis factor family.
Protein type: Cell cycle regulation; Cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q25
Cellular Component: cell surface; extracellular space; plasma membrane
Molecular Function: receptor binding; tumor necrosis factor receptor superfamily binding
Biological Process: acute inflammatory response; defense response to nematode; negative regulation of interferon-gamma production; negative regulation of interleukin-17 production; negative regulation of regulatory T cell differentiation; negative regulation of T-helper 1 cell differentiation; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell activation; positive regulation of CD4-positive, alpha beta T cell differentiation; positive regulation of cell proliferation; positive regulation of immunoglobulin mediated immune response; positive regulation of immunoglobulin secretion; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-6 production; positive regulation of memory T cell differentiation; positive regulation of T cell cytokine production; positive regulation of T cell proliferation; positive regulation of T-helper 2 cell differentiation; positive regulation of T-helper 2 type immune response; regulation of adaptive immune response; regulation of inflammatory response; response to virus; signal transduction; tumor necrosis factor-mediated signaling pathway
Disease: Myocardial Infarction, Susceptibility To
Research Articles on OX40L
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Product Notes
The OX40L tnfsf4 (Catalog #AAA488212) is a Recombinant Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-OX40L [R4930 (Oxelumab)] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's OX40L can be used in a range of immunoassay formats including, but not limited to, Block, Flow Cytometry (FC/FACS). This antibody binds to the co-stimulatory OX40L, inhibiting its interaction with OX40. Researchers should empirically determine the suitability of the OX40L tnfsf4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OX40L, Recombinant Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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