Hamster Non Metastatic Cells 1, Protein NM23A Expressed In ELISA Kit | NME1 elisa kit
Hamster Non Metastatic Cells 1, Protein NM23A Expressed In ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
Uniprot Description
NME1: an enzyme with multiple activities including histidine protein kinase, nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase and 3'-5' exonuclease activities. Plays a major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Involved in cell proliferation, differentiation and development, G protein-coupled receptor endocytosis, cytotoxic T cell and NK cell-mediated cell death, and gene expression. Required for neural development including neural patterning and cell fate determination. During granzyme A (GZMA)-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Three alternatively spliced human proteins have been reported.
Protein type: Tumor suppressor; EC 2.7.4.6; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; Kinase, other; Protein kinase, histidine; Kinase, nucleoside diphosphate; Other group; NDK family
Chromosomal Location of Human Ortholog: 17q21.3
Cellular Component: membrane; mitochondrion; cytoplasm; nucleus; cytosol
Molecular Function: identical protein binding; protein binding; GTP binding; deoxyribonuclease activity; magnesium ion binding; nucleoside diphosphate kinase activity; ribosomal small subunit binding; ATP binding
Biological Process: GTP biosynthetic process; nervous system development; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; UTP biosynthetic process; nucleoside diphosphate phosphorylation; endocytosis; DNA catabolic process; regulation of apoptosis; negative regulation of cell proliferation; CTP biosynthetic process; pyrimidine nucleotide metabolic process; nucleoside triphosphate biosynthetic process; cell differentiation; positive regulation of epithelial cell proliferation; purine nucleotide metabolic process; positive regulation of DNA binding
Disease: Neuroblastoma, Susceptibility To
Research Articles on NME1
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Product Notes
The Hamster NME1 nme1 (Catalog #AAA048751) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA048751 ELISA Kit recognizes Hamster NME1. It is sometimes possible for the material contained within the vial of "Non Metastatic Cells 1, Protein NM23A Expressed In, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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