Mouse anti-Human, Rat Stat6 Monoclonal Antibody | anti-Stat6 antibody

Anti-Stat6 Mouse mAb

Cat. Num. AAA476038

• Gene Names: STAT6; STAT6B; STAT6C; D12S1644; IL-4-STAT
• Reactivity: Human, Rat
• Applications: Western Blot
• Synonyms: Stat6; Monoclonal Antibody; Anti-Stat6 Mouse mAb; 12S1644; D12S1644; IL 4 STAT; IL-4 Stat; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal transducer and activator of transcription 6; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; interleukin 4 induced; STAT 6; STAT interleukin4 induced; STAT; interleukin4 induced; STAT6_HUMAN; STAT6B; STAT6C; Transcription factor IL 4 STAT; anti-Stat6 antibody

• Host: Mouse
• Reactivity: Human, Rat
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 2B2-B6-D7
• Form/Format: Ascitic fluid containing 0.03% sodium azide.
• Sequence Length: 847

• Applicable Applications for anti-Stat6 antibody: Western Blot (WB)
• Immunogen: Purified recombinant fragment of human STAT6 expressed in E Coli.
• Sequence Similarities: Contains 1 SH2 domain.
• Subunit Structure: Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.
• Subcellular Location: Nucleus

Western Blot (WB)

(Western blot detection of Stat6 in PC12, THP-1, Jurkat and MCF7 cell lysates using Stat6 mouse mAb (1:1000 diluted).Predicted band size:94KDa.Observed band size:110KDa.)

Immunofluorescence (IF)

(Immunofluorescence analysis of Hela cells using STAT6 mouse mAb (green). Blue)

Related Product Information for anti-Stat6 antibody

Entrez Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniPort Summary Function: Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.

NCBI and Uniprot Product Information

• NCBI GI #: 296010864
• NCBI GeneID: 6778
• NCBI Accession #: NP_001171549.1
• NCBI GenBank Nucleotide #: NM_001178078.1
• UniProt Accession #: P42226; Q5FBW5; Q71UP4; A8K316; B7ZA27; F5GXI9
• Molecular Weight: 94
• NCBI Official Full Name: signal transducer and activator of transcription 6 isoform 1
• NCBI Official Synonym Full Names: signal transducer and activator of transcription 6
• NCBI Official Symbol: STAT6
• NCBI Official Synonym Symbols: STAT6B; STAT6C; D12S1644; IL-4-STAT
• NCBI Protein Information: signal transducer and activator of transcription 6
• UniProt Protein Name: Signal transducer and activator of transcription 6
• Protein Family: Signal transducer and transcription activator
• UniProt Gene Name: STAT6

NCBI Description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Uniprot Description

STAT6: transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: identical protein binding; protein binding; protein phosphatase binding

Biological Process: positive regulation of interferon type I production; regulation of transcription from RNA polymerase II promoter; signal transduction