Rabbit Caspr2/CNTNAP2 Polyclonal Antibody | anti-Caspr2/CNTNAP2 antibody

Caspr2/CNTNAP2 Rabbit pAb

Cat. Num. AAA4754604

• Gene Names: CNTNAP2; CDFE; NRXN4; AUTS15; CASPR2; PTHSL1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity purified
• Synonyms: Caspr2/CNTNAP2; Polyclonal Antibody; Caspr2/CNTNAP2 Rabbit pAb; CDFE; NRXN4; AUTS15; CASPR2; PTHSL1; anti-Caspr2/CNTNAP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Purity/Purification: Affinity purified
• Form/Format: -20 degree C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

• Applicable Applications for anti-Caspr2/CNTNAP2 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:200-1:1000
• Immunogen: Fusion protein of human CNTNAP2
• Conjugation: Unconjugated
• Molecular Function: This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.
• Modification: Unmodified
• Cell Position: Cell junction, Cell projection, Membrane
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-3: Human cerebrum tissue, Mouse brain tissue and Rat brain tissue lysates, Primary antibody: 124418(CNTNAP2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 4 minutes)

Product Categories/Family for anti-Caspr2/CNTNAP2 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 109731182
• NCBI GeneID: 26047
• UniProt Accession #: Q9UHC6; Q14DG2; Q52LV1; Q5H9Q7; Q9UQ12; D3DWG2
• Molecular Weight: 11,899 Da
• NCBI Official Full Name: Homo sapiens contactin associated protein-like 2, mRNA
• NCBI Official Synonym Full Names: contactin associated protein-like 2
• NCBI Official Symbol: CNTNAP2
• NCBI Official Synonym Symbols: CDFE; NRXN4; AUTS15; CASPR2; PTHSL1
• NCBI Protein Information: contactin-associated protein-like 2
• UniProt Protein Name: Contactin-associated protein-like 2
• UniProt Gene Name: CNTNAP2

NCBI Description

This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.[provided by RefSeq, Mar 2010]

Uniprot Description

Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction.