Rabbit Tec Polyclonal Antibody | anti-TEC antibody

Tec Rabbit pAb

Cat. Num. AAA4752299

• Gene Names: TEC; PSCTK4
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Flow Cytometry, Functional Assay
• Purity: Affinity purified
• Synonyms: Tec; Polyclonal Antibody; Tec Rabbit pAb; Tyrosine-protein kinase Tec; anti-TEC antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages. Gene expression databases
• Purity/Purification: Affinity purified
• Form/Format: Supplied in 50nM Tris-Glycine (pH7.4), 0.15M Nacl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

• Applicable Applications for anti-TEC antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS)
• Application Notes: WB: 1:2000; IHC: 1:20; ICC/IF: 1:20-1:100; FC/FACS: 1:20
• Immunogen: A synthetic peptide of human Tec
• Conjugation: Unconjugated
• Modification: Unmodification
• Subcellular Location: Cell membrane, Cytoplasm, Cytoskeleton, Membrane
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot detection of Tec in K562 cell lysates using Tec Rabbit pAb(1:1000 diluted). Predicted band size:74kDa. Observed band size:58-75kDa.)

Related Product Information for anti-TEC antibody

Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation.

NCBI and Uniprot Product Information

• NCBI GI #: 130977759
• NCBI GeneID: 7006
• NCBI Accession #: NP_003206.2
• NCBI GenBank Nucleotide #: NM_003215.2
• UniProt Accession #: P42680; Q3MIS5; B7ZKZ6
• Molecular Weight: 631
• NCBI Official Full Name: tyrosine-protein kinase Tec
• NCBI Official Synonym Full Names: tec protein tyrosine kinase
• NCBI Official Symbol: TEC
• NCBI Official Synonym Symbols: PSCTK4
• NCBI Protein Information: tyrosine-protein kinase Tec
• UniProt Protein Name: Tyrosine-protein kinase Tec
• Protein Family: Tectonic
• UniProt Gene Name: TEC
• UniProt Synonym Gene Names: PSCTK4
• UniProt Entry Name: TEC_HUMAN