Coronin-1B Phospho-Regulation Antibody Sampler Kit
Coronin-1B Phospho-Regulation
Reactivity
Human, Rat, Mouse
Applications
Western Blot, ELISA, Immunocytochemistry
Synonyms
Coronin-1B Phospho-Regulation; Coronin 1BK; Coronin-1B Phospho-Regulation antibody sampler kit
Reactivity
Human, Rat, Mouse
Form/Format
Rabbit polyclonal antibodies are supplied in phosphate-buffered saline (PBS), 50% glycerol, 1mg/ml BSA, and 0.05% sodium azide. The secondary reagents are supplied in the same buffer without azide, and the peptides are supplied in PBS and 0.05% sodium azi
Applicable Applications for Coronin-1B Phospho-Regulation antibody sampler kit
Western Blot (WB), ELISA (EIA), Immunocytochemistry (ICC)
Preparation and Storage
Store all at -20 degree C. Stable for 1 year.
Related Product Information for Coronin-1B Phospho-Regulation antibody sampler kit
Kit Summary: The coronin-1B phospho-regulation antibody sampler kit can be used to detect the level of phosphorylation of coronin-1B(Ser-2) relative to the total expression level of coronin-1B. The kit also includes peptides for antibody blockingexperiments and a secondary reagent for antibody detection.
Background: Coronins are highly-conserved F-actin binding proteins that play important roles in lamellipodial protrusion during varioustypes of cell motility. In yeast, coronins regulate cytoskeletal changes through inhibition of Arp2/3 complex. Humancoronins have been classified in three subgroups: type I (coronin-1A, -1B, -1C), type II (coronin-2A, -2B), and type III(coronin-7). These coronins have at least one large beta-propeller region that mediates protein-protein interactions and type Iand II coronins have coiled-coil regions involved in oligiomerization. Coronin-1B is ubiquitously expressed and localizes tothe leading edge of cell protrusions in migrating fibroblasts. Both Coronin-1B and Coronin-1A interaction with Arp2/3complex may be regulated by phosphorylation. PKC phosphorylates the N-terminus at Ser-2, and this phosphorylationreduces interactions with Arp2/3 leading to diminished cell motility.
Background: Coronins are highly-conserved F-actin binding proteins that play important roles in lamellipodial protrusion during varioustypes of cell motility. In yeast, coronins regulate cytoskeletal changes through inhibition of Arp2/3 complex. Humancoronins have been classified in three subgroups: type I (coronin-1A, -1B, -1C), type II (coronin-2A, -2B), and type III(coronin-7). These coronins have at least one large beta-propeller region that mediates protein-protein interactions and type Iand II coronins have coiled-coil regions involved in oligiomerization. Coronin-1B is ubiquitously expressed and localizes tothe leading edge of cell protrusions in migrating fibroblasts. Both Coronin-1B and Coronin-1A interaction with Arp2/3complex may be regulated by phosphorylation. PKC phosphorylates the N-terminus at Ser-2, and this phosphorylationreduces interactions with Arp2/3 leading to diminished cell motility.
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Product Notes
The Human, Rat, Mouse Coronin-1B Phospho-Regulation (Catalog #AAA474204) is an Antibody Sampler Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA474204 Antibody Sampler Kit recognizes Human, Rat, Mouse Coronin-1B Phospho-Regulation. AAA Biotech's Coronin-1B Phospho-Regulation can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunocytochemistry (ICC). Researchers should empirically determine the suitability of the Coronin-1B Phospho-Regulation for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Coronin-1B Phospho-Regulation, Antibody Sampler Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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