Western Blot (WB)
( Western Blot: The whole cell lysate derived from HT-29 (lane 1), Mouse Liver (lane 2), mouse lung (lane 3) were immunoblotted by Rabbit anti-PCSK9 (Cat#MBS462174))
Rabbit PCSK9 Antibody | anti-PCSK9 antibody
Rabbit anti PCSK9 antibody
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Western Blot (WB)
( Western Blot: The whole cell lysate derived from HT-29 (lane 1), Mouse Liver (lane 2), mouse lung (lane 3) were immunoblotted by Rabbit anti-PCSK9 (Cat#MBS462174))
Western Blot (WB)
( Western Blot: The whole cell lysate derived from HT-29 (lane 1), Mouse Liver (lane 2), mouse lung (lane 3) were immunoblotted by Rabbit anti-PCSK9 (Cat#MBS462174))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq]
Uniprot Description
Function: May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
Cofactor: Calcium
Probable.
Enzyme regulation: Inhibited by EGTA.
Subunit structure: The precursor protein but not the mature protein may form multimers.
Subcellular location: Secreted.
Tissue specificity: Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
Post-translational modification: The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.
Polymorphism: Variant Leu-23 ins polymorphism in PCSK9 might have a modifier effect on LDLR mutation and familial hypercholesterolemia.
Involvement in disease: Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [
MIM:603776]. FH3 inheritance is autosomal dominant. Ref.13
Sequence similarities: Belongs to the peptidase S8 family.Contains 1 peptidase S8 domain.
Sequence caution: The sequence BAC11572.1 differs from that shown. Reason: Frameshift at position 494.
Research Articles on PCSK9
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Product Notes
The PCSK9 pcsk9 (Catalog #AAA462174) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti PCSK9 antibody reacts with Human, Rat, Mouse, Gorilla and may cross-react with other species as described in the data sheet. AAA Biotech's PCSK9 can be used in a range of immunoassay formats including, but not limited to, ELISA, Western Blot, Immunohistochemistry. Western Blot: 0.1-1 ug/ml ELISA: 0.01-0.1 ug/ml Immunoprecipitation: 2-5 ug/ml. Researchers should empirically determine the suitability of the PCSK9 pcsk9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PCSK9, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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