Mouse Coagulation Factor II (F2) ELISA Kit | F2 elisa kit

Mouse Coagulation Factor II (F2) ELISA Kit

Cat. Num. AAA453797

• Gene Names: F2; Cf2; FII; Cf-2
• Reactivity: Mouse
• Synonyms: Coagulation Factor II (F2); Mouse Coagulation Factor II (F2) ELISA Kit; FII; TM; PT; Thrombin; Prothrombin; Pro-Thrombin; Activation peptide fragment 1; Activation peptide fragment 2; F2 elisa kit

• Reactivity: Mouse
• Sequence Length: 618

• Samples: Plasma.
• Assay Type: Sandwich
• Detection Range: 1.56-100ng/mL
• Sensitivity: 0.59ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 6753798
• NCBI GeneID: 14061
• NCBI Accession #: NP_034298.1
• NCBI GenBank Nucleotide #: NM_010168.3
• UniProt Accession #: P19221
• Molecular Weight: 70,269 Da
• NCBI Official Full Name: prothrombin preproprotein
• NCBI Official Synonym Full Names: coagulation factor II
• NCBI Official Symbol: F2
• NCBI Official Synonym Symbols: Cf2; FII; Cf-2
• NCBI Protein Information: prothrombin
• UniProt Protein Name: Prothrombin
• Protein Family: Prothrombin
• UniProt Gene Name: F2
• UniProt Synonym Gene Names: Cf2

NCBI Description

This gene encodes a vitamin K-dependent glycoprotein coagulation factor that plays an important role in the process of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that undergoes enzymatic cleavage by the coagulation factor Xa to form an active serine protease that converts soluble fibrinogen to insoluble fibrin clot. Most of the mice lacking the encoded protein die at an embryonic stage due to defects in yolk sac vasculature, while the rare nenonates succumb to hemorrhage on the first postnatal day. [provided by RefSeq, Apr 2015]

Uniprot Description

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing ().