Bcl-2 peptide
Bcl-2 (A18) Blocking Peptide
NCBI and Uniprot Product Information
NCBI Description
an anti-apoptotic protein; involved in inhibiting cell death in many different cell types [RGD, Feb 2006]
Uniprot Description
Bcl-2: a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions.
Protein type: Membrane protein, integral; Oncoprotein; Apoptosis; Autophagy
Cellular Component: endoplasmic reticulum membrane; nuclear membrane; mitochondrion; endoplasmic reticulum; cell; integral to membrane; cytosol; pore complex; mitochondrial outer membrane; membrane; mitochondrial membrane; cytoplasm; intracellular; nucleus; myelin sheath
Molecular Function: identical protein binding; BH domain binding; protein homodimerization activity; protease binding; protein phosphatase 2A binding; channel activity; channel inhibitor activity; transcription factor binding; protein phosphatase binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding; ubiquitin protein ligase binding; BH3 domain binding
Biological Process: positive regulation of catalytic activity; focal adhesion formation; developmental growth; pigment granule organization and biogenesis; regulation of cell cycle; response to toxin; ear development; B cell receptor signaling pathway; negative regulation of myeloid cell apoptosis; regulation of protein localization; negative regulation of ossification; oligodendrocyte differentiation; regulation of transmembrane transporter activity; negative regulation of neuron apoptosis; kidney development; T cell differentiation; response to drug; spleen development; positive regulation of neuron maturation; axon regeneration; cell aging; regulation of calcium ion transport; positive regulation of cell growth; response to ethanol; DNA damage response, signal transduction resulting in induction of apoptosis; response to heat; regulation of gene expression; response to estrogen stimulus; negative regulation of osteoblast proliferation; response to oxidative stress; lymphocyte homeostasis; negative regulation of apoptosis; positive regulation of pigmentation; positive regulation of smooth muscle cell migration; response to L-ascorbic acid; response to insulin stimulus; response to organic substance; negative regulation of cell proliferation; positive regulation of skeletal muscle fiber development; ureteric bud development; positive regulation of cell proliferation; negative regulation of cell migration; transmembrane transport; regulation of viral genome replication; response to nutrient; aging; leukocyte homeostasis; response to aluminum ion; mesenchymal cell development; response to inorganic substance; CD8-positive, alpha-beta T cell lineage commitment; B cell lineage commitment; positive regulation of peptidyl-serine phosphorylation; response to UV-B; cell proliferation; endoplasmic reticulum calcium ion homeostasis; peptidyl-serine phosphorylation; pigmentation; response to copper ion; homeostasis of number of cells within a tissue; ureteric bud branching; response to hypoxia; brain development; negative regulation of cell growth; response to nicotine; renal system process; protein polyubiquitination; response to glucocorticoid stimulus; T cell differentiation in the thymus; lymphoid progenitor cell differentiation; positive regulation of multicellular organism growth; response to organic cyclic substance; glomerulus development; post-embryonic development; response to caffeine; regulation of apoptosis; cochlear nucleus development; cellular response to glucose starvation; cell-cell adhesion; regulation of mitochondrial membrane potential; response to folic acid; positive regulation of B cell proliferation; T cell homeostasis; negative regulation of mitotic cell cycle; cell growth; response to electrical stimulus; defense response to virus; response to corticosterone stimulus; release of cytochrome c from mitochondria; regulation of protein homodimerization activity; actin filament organization; digestive tract morphogenesis; organ growth; organ morphogenesis; induction of apoptosis via death domain receptors; response to steroid hormone stimulus; B cell differentiation; gland morphogenesis; regulation of pigmentation during development; regulation of mitochondrial membrane permeability; regulation of nitrogen utilization; metanephros development; oocyte development; B cell proliferation; response to peptide hormone stimulus; regulation of protein heterodimerization activity; response to cAMP; behavioral fear response; melanin metabolic process; apoptosis; negative regulation of retinal cell programmed cell death; regulation of cell-matrix adhesion; pigmentation during development; cell morphogenesis; regulation of protein stability; protein amino acid dephosphorylation; apoptotic mitochondrial changes; B cell homeostasis; ovarian follicle development; regulation of catalytic activity; positive regulation of melanocyte differentiation; melanocyte differentiation; response to gamma radiation; hemopoiesis; response to iron ion; negative regulation of cellular pH reduction; ossification; hair follicle morphogenesis; thymus development; male gonad development; peptidyl-threonine phosphorylation; regulation of programmed cell death; cellular calcium ion homeostasis; immune system development; T cell lineage commitment; neuron apoptosis; axonogenesis; response to hydrogen peroxide; response to cytokine stimulus; response to DNA damage stimulus; induction of apoptosis by oxidative stress; growth
Research Articles on Bcl-2
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Product Notes
The Bcl-2 bcl2 (Catalog #AAA443001) is a Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Bcl-2, Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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