IL1R2 blocking peptide

IL1R2 Immunizing Peptide

Gene Names

IL1R2; IL1RB; CD121b; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2

Reactivity

Human

Synonyms

IL1R2; IL1R2 Immunizing Peptide; interleukin 1 receptor; type II; CD121b; IL1RB; MGC47725; antigen CDw121b; type II interleukin-1 receptor; beta; IL1R2 blocking peptide

Ordering
Cat. Num. AAA427307 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Reactivity

Human

Form/Format

100ug of dried peptide

Sequence

C-QYNITRSIELRIKK

Sequence Length

398

Preparation and Storage

Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

NCBI GI #

4758598

NCBI GeneID

7850

NCBI Accession #

NP_004624.1; NP_001248348.1

NCBI GenBank Nucleotide #

NM_004633.3

Molecular Weight

33,622 Da

NCBI Official Full Name

interleukin-1 receptor type 2 isoform 1

NCBI Official Synonym Full Names

interleukin 1 receptor type 2

NCBI Official Symbol

IL1R2

NCBI Official Synonym Symbols

IL1RB; CD121b; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2

NCBI Protein Information

interleukin-1 receptor type 2

UniProt Protein Name

Interleukin-1 receptor type 2

Protein Family

Interleukin-1 receptor

UniProt Gene Name

IL1R2

UniProt Synonym Gene Names

IL1RB; IL-1R-2; IL-1RT-2; IL-1RT2; IL-1R-beta; mIL-1R2; mIL-1RII; sIL-1R2; sIL-1RII

UniProt Entry Name

IL1R2_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]

Uniprot Description

IL-1RB: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Belongs to the interleukin-1 receptor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: extracellular region; integral to membrane; plasma membrane

Molecular Function: interleukin-1 receptor activity; interleukin-1, Type II, blocking receptor activity; protein binding

Biological Process: cytokine and chemokine mediated signaling pathway; immune response

Research Articles on IL1R2

1. Suggest IL-1R2 as potential biomarker of acute respiratory distress syndrome.

Similar Products

IL-1R2 CLIA Kit

Host: n/a

Reactivity: Human

Apps: n/a

Product Notes

The IL1R2 il1r2 (Catalog #AAA427307) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The IL1R2 Immunizing Peptide reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-QYNITRSI ELRIKK. It is sometimes possible for the material contained within the vial of "IL1R2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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