NFATC2 / NFAT1 Blocking Peptide | NFATC2 blocking peptide
NFATC2 / NFAT1 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]
Uniprot Description
NFAT1: a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha and GM-CSF. It is present in a phosphorylated the cytosol of unstimulated T cells. After T-cell activation, it is dephosphorylated by calcineurin and translocates to the nucleus as a part of a transcription complex. Two splice variant isoforms have been identified.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 20q13.2
Cellular Component: actin cytoskeleton; cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane; ribonucleoprotein complex
Molecular Function: chromatin binding; DNA binding; protein binding; transcription factor activity; transcription factor binding
Biological Process: B cell receptor signaling pathway; calcineurin-NFAT signaling pathway; cell migration; cytokine production; myotube cell development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of B cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to drug; transcription from RNA polymerase II promoter
Research Articles on NFATC2
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Product Notes
The NFATC2 nfatc2 (Catalog #AAA426647) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The NFATC2 / NFAT1 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-QQFRTGLS SPDARYQ. It is sometimes possible for the material contained within the vial of "NFATC2 / NFAT1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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