USP28 blocking peptide
USP28 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).[supplied by OMIM, Mar 2008]
Uniprot Description
USP28: a peptidase of the C19 family. USP28 and FBXW7 regulate Myc protein stability in response to DNA damage. Two isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin-specific protease; Protease; EC 3.4.19.12
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus; protein complex
Molecular Function: protein binding; ubiquitin-specific protease activity
Biological Process: cell proliferation; DNA damage checkpoint; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; DNA repair; protein deubiquitination; Ras protein signal transduction; regulation of protein stability; response to DNA damage stimulus; response to ionizing radiation; ubiquitin-dependent protein catabolic process
Research Articles on USP28
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Product Notes
The USP28 usp28 (Catalog #AAA426501) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The USP28 Immunizing Peptide reacts with Human, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-SVELKHYI QEDN. It is sometimes possible for the material contained within the vial of "USP28, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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