TBL1X / TBL1XR1 Blocking Peptide | TBL1X blocking peptide

TBL1X / TBL1XR1 Immunizing Peptide

Cat. Num. AAA426328

• Gene Names: TBL1X; EBI; TBL1; SMAP55
• Reactivity: Human, Mouse, Rat, Dog, Cow
• Synonyms: TBL1X / TBL1XR1; TBL1X / TBL1XR1 Immunizing Peptide; TBL1X; TBL1XR1; EBI; TBL1; transducin (beta)-like 1X-linked; transducin (beta)-like 1; transducin (beta)-like 1 X-linked; transducin (beta)-like 1X-linked receptor 1; C21; DC42; FLJ12894; IRA1; TBLR1; TBL1-related protein 1; nuclear receptor co-repressor; TBL1X blocking peptide

• Reactivity: Human, Mouse, Rat, Dog, Cow
• Form/Format: 100ug of dried peptide
• Sequence: SASDGSVCVLDLRK
• Sequence Length: 577

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 5032159
• NCBI GeneID: 6907
• NCBI Accession #: NP_005638.1; NP_001132938.1; NP_001132939.1; NP_001132940.1; NP_078941.2
• NCBI GenBank Nucleotide #: NM_005647.3
• Molecular Weight: 57,049 Da
• NCBI Official Full Name: F-box-like/WD repeat-containing protein TBL1X isoform a
• NCBI Official Synonym Full Names: transducin (beta)-like 1X-linked
• NCBI Official Symbol: TBL1X
• NCBI Official Synonym Symbols: EBI; TBL1; SMAP55
• NCBI Protein Information: F-box-like/WD repeat-containing protein TBL1X
• UniProt Protein Name: F-box-like/WD repeat-containing protein TBL1X
• Protein Family: F-box-like/WD repeat-containing protein
• UniProt Gene Name: TBL1X
• UniProt Synonym Gene Names: TBL1
• UniProt Entry Name: TBL1X_HUMAN

NCBI Description

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008]

Uniprot Description

TBL1X: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. Belongs to the WD repeat EBI family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: Xp22.3

Cellular Component: histone deacetylase complex; nucleoplasm; nucleus; spindle microtubule; transcriptional repressor complex

Molecular Function: beta-catenin binding; histone binding; protein binding; protein C-terminus binding; protein domain specific binding; transcription corepressor activity; transcription factor binding

Biological Process: cellular lipid metabolic process; histone deacetylation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; proteolysis; sensory perception of sound; transcription, DNA-dependent; Wnt receptor signaling pathway through beta-catenin