LGP2 Blocking Peptide | DHX58 blocking peptide

LGP2 Immunizing Peptide

Cat. Num. AAA426292

• Gene Names: DHX58; LGP2; RLR-3; D11LGP2; D11lgp2e
• Reactivity: Human
• Synonyms: LGP2; LGP2 Immunizing Peptide; DHX58; DEXH (Asp-Glu-X-His) box polypeptide 58; D11LGP2; D11lgp2e; RNA helicase LGP2; ortholog of mouse D11lgp2; DHX58 blocking peptide

• Reactivity: Human
• Form/Format: 100ug of dried peptide
• Sequence: DFLQHCAENLSD
• Sequence Length: 678

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 149408122
• NCBI GeneID: 79132
• NCBI Accession #: NP_077024.2
• NCBI GenBank Nucleotide #: NM_024119.2
• Molecular Weight: 76,613 Da
• NCBI Official Full Name: probable ATP-dependent RNA helicase DHX58
• NCBI Official Synonym Full Names: DEXH-box helicase 58
• NCBI Official Symbol: DHX58
• NCBI Official Synonym Symbols: LGP2; RLR-3; D11LGP2; D11lgp2e
• NCBI Protein Information: probable ATP-dependent RNA helicase DHX58
• UniProt Protein Name: Probable ATP-dependent RNA helicase DHX58
• Protein Family: Probable ATP-dependent RNA helicase
• UniProt Gene Name: DHX58
• UniProt Synonym Gene Names: D11LGP2E; LGP2; RLR-3; RLR
• UniProt Entry Name: DHX58_HUMAN

Uniprot Description

DHX58: Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate. Belongs to the helicase family. RLR subfamily.

Protein type: Inhibitor; EC 3.6.4.13; Helicase

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoplasm

Molecular Function: ATP binding; DNA binding; double-stranded RNA binding; helicase activity; protein binding; single-stranded RNA binding; zinc ion binding

Biological Process: defense response to virus; innate immune response; metabolic process; negative regulation of innate immune response; negative regulation of interferon type I production; positive regulation of interferon type I production; regulation of innate immune response; response to virus; viral reproduction