MEL18 / PCGF2 Blocking Peptide | PCGF2 blocking peptide
MEL18 / PCGF2 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]
Uniprot Description
PCGF2: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with Bmi1; unlike Bmi1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex.
Protein type: Ubiquitin conjugating system; Ubiquitin ligase; Transcription factor
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: nuclear body; nuclear chromatin; nucleoplasm; nucleus; PcG protein complex; sex chromatin
Molecular Function: chromatin binding; DNA binding; protein binding; transcription factor activity; zinc ion binding
Biological Process: anterior/posterior pattern formation; embryonic skeletal morphogenesis; histone acetylation; in utero embryonic development; negative regulation of transcription from RNA polymerase II promoter; protein sumoylation; transcription, DNA-dependent
Research Articles on PCGF2
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Product Notes
The PCGF2 pcgf2 (Catalog #AAA426090) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The MEL18 / PCGF2 Immunizing Peptide reacts with Human, Dog, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-KMTVNGAP VPPLT. It is sometimes possible for the material contained within the vial of "MEL18 / PCGF2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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