CENTD2 / ARAP1 Blocking Peptide | ARAP1 blocking peptide

CENTD2 / ARAP1 Immunizing Peptide

Cat. Num. AAA425671

• Gene Names: ARAP1; CENTD2
• Reactivity: Human, Mouse, Rat, Dog, Pig, Cow
• Synonyms: CENTD2 / ARAP1; CENTD2 / ARAP1 Immunizing Peptide; ARAP1; CENTD2; centaurin; delta 2; KIAA0782; ARF-GAP; RHO-GAP; ankyrin repeat; and pleckstrin homology domains-containing protein 1; ArfGAP with RhoGAP domain; ankyrin repeat and PH domain 1; OTTHUMP00000211462; ARAP1 blocking peptide

• Reactivity: Human, Mouse, Rat, Dog, Pig, Cow
• Form/Format: 100ug of dried peptide
• Sequence: C-AFTADPLSLLRNV
• Sequence Length: 1205

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 206597513
• NCBI GeneID: 116985
• NCBI Accession #: NP_056057.2; NP_001035207.1; NP_001128662.1
• NCBI GenBank Nucleotide #: NM_015242.4
• Molecular Weight: 127,665 Da
• NCBI Official Full Name: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform a
• NCBI Official Synonym Full Names: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
• NCBI Official Symbol: ARAP1
• NCBI Official Synonym Symbols: CENTD2
• NCBI Protein Information: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
• UniProt Protein Name: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
• Protein Family: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein
• UniProt Gene Name: ARAP1
• UniProt Synonym Gene Names: CENTD2; KIAA0782; Cnt-d2
• UniProt Entry Name: ARAP1_HUMAN

NCBI Description

The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Uniprot Description

CENTD2: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, ARF; Motility/polarity/chemotaxis; GAPs

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: cytoplasmic vesicle; cytosol; Golgi apparatus; plasma membrane; trans-Golgi network

Molecular Function: GTPase activator activity; metal ion binding; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; type 1 angiotensin receptor binding

Biological Process: actin filament reorganization during cell cycle; negative regulation of stress fiber formation; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of filopodium formation; positive regulation of GTPase activity; positive regulation of receptor recycling; regulation of cell motility; regulation of cell shape; regulation of small GTPase mediated signal transduction; signal transduction