Centromere protein F / mitosin Blocking Peptide | CENPF blocking peptide

Centromere protein F / mitosin Immunizing Peptide

Cat. Num. AAA425369

• Gene Names: CENPF; CENF; hcp-1; CILD31; STROMS; PRO1779
• Reactivity: Human, Cow
• Synonyms: Centromere protein F / mitosin; Centromere protein F / mitosin Immunizing Peptide; CENPF; centromere protein F (350/400kD; mitosin); CENF; PRO1779; mitosin; AH antigen; CENP-F kinetochore protein; centromere protein F (400kD); cell-cycle-dependent 350K nuclear protein; centromere protein F; 350/400ka (mitosin); RP11-262H5.1; hcp-1; cent; Centromere protein F; Mitosin; CENPF blocking peptide

• Reactivity: Human, Cow
• Form/Format: 100ug of dried peptide
• Sequence: GLESKGSENCKVQ
• Sequence Length: 3210

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 924601
• NCBI GeneID: 1063
• Molecular Weight: 367,764 Da
• NCBI Official Full Name: CENP-F kinetochore protein
• NCBI Official Synonym Full Names: centromere protein F
• NCBI Official Symbol: CENPF
• NCBI Official Synonym Symbols: CENF; hcp-1; CILD31; STROMS; PRO1779
• NCBI Protein Information: centromere protein F
• UniProt Protein Name: Centromere protein F
• Protein Family: Centromere protein
• UniProt Gene Name: CENPF
• UniProt Synonym Gene Names: CENP-F
• UniProt Entry Name: CENPF_HUMAN

NCBI Description

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]

Uniprot Description

CENPF: a nuclear matrix protein that assembles onto kinetochores at late G2. Is hyperphosphorylated during mitosis and rapidly degraded after mitosis. Involved in chromosome segregation during mitosis. Interacts with retinoblastoma protein (RB), CENP-E and BUBR1. Two alternatively spliced human isoforms have been described.

Protein type: Transcription, coactivator/corepressor; Nuclear envelope; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: axoneme; centrosome; chromatin; chromosome, pericentric region; cytoplasm; cytosol; kinetochore; midbody; nuclear envelope; nuclear matrix; nucleoplasm; nucleus; outer kinetochore of condensed chromosome; perinuclear region of cytoplasm; pronucleus; spindle; spindle pole

Molecular Function: chromatin binding; dynein binding; protein binding; protein C-terminus binding; protein homodimerization activity; transcription factor binding

Biological Process: cell differentiation; cell division; cell proliferation; chromosome segregation; kidney development; kinetochore assembly; metaphase plate congression; mitosis; mitotic cell cycle; mitotic cell cycle spindle assembly checkpoint; muscle development; negative regulation of transcription, DNA-dependent; protein transport; regulation of cell cycle; regulation of G2/M transition of mitotic cell cycle; regulation of striated muscle development; response to drug; sister chromatid cohesion; ventricular system development

Disease: Ciliary Dyskinesia, Primary, 31; Stromme Syndrome