TFB1M blocking peptide
TFB1M Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).[provided by RefSeq, Aug 2010]
Uniprot Description
TFB1M: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA. Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
Protein type: Methyltransferase; EC 2.1.1.-
Chromosomal Location of Human Ortholog: 6q25.1-q25.3
Cellular Component: mitochondrial matrix
Molecular Function: DNA binding; protein binding; rRNA (adenine-N6,N6-)-dimethyltransferase activity
Biological Process: mitochondrion organization and biogenesis; regulation of transcription, DNA-dependent; rRNA methylation; transcription, DNA-dependent
Research Articles on TFB1M
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Product Notes
The TFB1M tfb1m (Catalog #AAA425054) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The TFB1M Immunizing Peptide reacts with Human, Dog and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-ELKRRKSK NEEKE. It is sometimes possible for the material contained within the vial of "TFB1M, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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