Western Blot (WB)
((1ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Goat Estrogen receptor beta Polyclonal Antibody | anti-ESR2 antibody
Goat anti-Estrogen receptor beta (aa417-428) Antibody
Western Blot: Approx 50kDa band observed in Human Placenta lysates (calculated MW of 53. 0kDa according to NP_001035366.1). Recommended concentration: 1-3ug/ml.
Western Blot (WB)
((1ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Western Blot (WB)
((1ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
Protein type: Nuclear receptor; DNA-binding
Chromosomal Location of Human Ortholog: 14q23.2
Cellular Component: cilium; extracellular region; mitochondrion; neuron projection; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; plasma membrane
Molecular Function: DNA binding; drug binding; enzyme binding; estrogen receptor activity; estrogen response element binding; ligand-dependent nuclear receptor activity; peroxisome proliferator activated receptor binding; protein binding; receptor antagonist activity; steroid binding; steroid hormone receptor activity; transcription coactivator activity; transcription factor activity; zinc ion binding
Biological Process: amygdala development; behavioral fear response; cell-cell signaling; cerebellum development; estrogen receptor signaling pathway; hypothalamus development; learning and/or memory; negative regulation of cell growth; negative regulation of epithelial cell proliferation; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; ovarian follicle development; positive regulation of apoptosis; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of vasodilation; prostate gland development; regulation of neuron apoptosis; regulation of transcription, DNA-dependent; response to activity; response to ethanol; response to genistein; response to insecticide; response to nutrient levels; response to testosterone stimulus; response to water deprivation; Sertoli cell development; Sertoli cell proliferation; signal transduction; transcription initiation from RNA polymerase II promoter
Research Articles on ESR2
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Product Notes
The ESR2 esr2 (Catalog #AAA422960) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-Estrogen receptor beta (aa417-428) Antibody reacts with Tested: Human; Expected from sequence similarity: Human and may cross-react with other species as described in the data sheet. AAA Biotech's Estrogen receptor beta can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Approx 50kDa band observed in Human Placenta lysates (calculated MW of 53. 0kDa according to NP_001035366.1). Recommended concentration: 1-3ug/ml. Researchers should empirically determine the suitability of the ESR2 esr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: TQDADSSRKL AH. It is sometimes possible for the material contained within the vial of "Estrogen receptor beta, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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