Goat ABCG4 Polyclonal Antibody | anti-ABCG4 antibody

Goat anti-ABCG4 Antibody

Cat. Num. AAA422232

• Gene Names: ABCG4; WHITE2
• Reactivity: Expected from sequence similarity: Human, Mouse, Rat, Dog
• Applications: ELISA
• Purity: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Synonyms: ABCG4; Polyclonal Antibody; Goat anti-ABCG4 Antibody; ATP-binding cassette; sub-family G (WHITE); member 4; WHITE2; subfamily G; putative ABC transporter; ABCG4 antibody; member 4 antibody; WHITE2 antibody; putative ABC transporter antibody; anti-ABCG4 antibody

• Host: Goat
• Reactivity: Expected from sequence similarity: Human, Mouse, Rat, Dog
• Clonality: Polyclonal
• Purity/Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Form/Format: Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Concentration: 100ug specific antibody in 200ul (varies by lot)
• Sequence: YLVLRYRVKSER
• Sequence Length: 646

• Applicable Applications for anti-ABCG4 antibody: Peptide ELISA (EIA)
• Application Notes: Peptide ELISA: Antibody detection limit dilution 1: 8000.; Western Blot: Preliminary experiments in Human Brain (Cerebellum, Frontal Cortex, Hippocampus) and in Mouse Eye and Rat Retina lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
• Immunogen: Peptide with sequence C-YLVLRYRVKSER, from the C Terminus of the protein sequence according to NP_071452.2.
• Epitope: C Terminus
• Preparation and Storage: Aliquot and store at -20 degree C. Minimize freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 20143975
• NCBI GeneID: 64137
• NCBI Accession #: NP_071452.2
• NCBI GenBank Nucleotide #: NM_022169.4
• Molecular Weight: 60,903 Da
• NCBI Official Full Name: ATP-binding cassette sub-family G member 4
• NCBI Official Synonym Full Names: ATP binding cassette subfamily G member 4
• NCBI Official Symbol: ABCG4
• NCBI Official Synonym Symbols: WHITE2
• NCBI Protein Information: ATP-binding cassette sub-family G member 4
• UniProt Protein Name: ATP-binding cassette sub-family G member 4
• Protein Family: ABC transporter G family
• UniProt Gene Name: ABCG4
• UniProt Synonym Gene Names: WHITE2
• UniProt Entry Name: ABCG4_HUMAN

NCBI Description

The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

ABCG4: May be involved in macrophage lipid homeostasis. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

Protein type: Transporter; Membrane protein, integral; Transporter, ABC family; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: integral to membrane; plasma membrane

Molecular Function: ATP binding; cholesterol transporter activity; protein binding; protein heterodimerization activity; protein homodimerization activity; sterol-transporting ATPase activity

Biological Process: cholesterol efflux; metabolic process; transmembrane transport