Goat INO80 Polyclonal Antibody | anti-INO80 antibody
Goat anti-INO80 Antibody
Western Blot: Preliminary experiments in Human Brain (Cerebellum) and Human Testis lysates and in lysates of cell lines HeLa and K562 gave no specific signal but low background (at antibody concentration up to 1ug/ml).
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Description
INOC1: DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle. Belongs to the SNF2/RAD54 helicase family.
Protein type: EC 3.6.4.12; Helicase; DNA-binding
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: microtubule; nucleus
Molecular Function: actin binding; alpha-tubulin binding; ATP binding; ATPase activity; DNA binding; DNA helicase activity; protein binding
Biological Process: cell division; chromatin remodeling; DNA duplex unwinding; double-strand break repair; double-strand break repair via homologous recombination; mitotic sister chromatid segregation; positive regulation of cell growth; positive regulation of transcription from RNA polymerase II promoter; spindle assembly; transcription, DNA-dependent
Research Articles on INO80
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Product Notes
The INO80 ino80 (Catalog #AAA422086) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-INO80 Antibody reacts with Expected from sequence similarity: Human, Rat Dog, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's INO80 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 4000. Western Blot: Preliminary experiments in Human Brain (Cerebellum) and Human Testis lysates and in lysates of cell lines HeLa and K562 gave no specific signal but low background (at antibody concentration up to 1ug/ml). Researchers should empirically determine the suitability of the INO80 ino80 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: TQEDYDSNHF KAQ. It is sometimes possible for the material contained within the vial of "INO80, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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