Goat ALS Polyclonal Antibody | anti-IGFALS antibody

Goat anti-ALS Antibody

Cat. Num. AAA421636

• Gene Names: IGFALS; ALS; ACLSD
• Reactivity: Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow, Pig
• Applications: ELISA
• Purity: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Synonyms: ALS; Polyclonal Antibody; Goat anti-ALS Antibody; IGFALS; insulin-like growth factor binding protein; acid labile subunit; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN COMPLEX ACID LABILE CHAIN; IGFALS antibody; acid labile subunit antibody; ALS antibody; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN COMPLEX ACID LABILE CHAIN antibody; anti-IGFALS antibody

• Host: Goat
• Reactivity: Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow, Pig
• Clonality: Polyclonal
• Purity/Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Form/Format: Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Concentration: 100ug specific antibody in 200ul (varies by lot)
• Sequence: GLDLRDLSEAH
• Sequence Length: 605

• Applicable Applications for anti-IGFALS antibody: Peptide ELISA (EIA)
• Application Notes: Peptide ELISA: Antibody detection limit dilution 1: 16000.; Western Blot: Preliminary experiments gave an approx 45kDa band in lysates of cell line HepG2 after 2ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 66. 0kDa according to NP_004961.1. The 45kDa band was successfully blocked by incubation with the immunizing peptide.
• Immunogen: Peptide with sequence C-GLDLRDLSEAH, from the C Terminus of the protein sequence according to NP_004961.1.
• Epitope: C Terminus
• Preparation and Storage: Aliquot and store at -20 degree C. Minimize freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 4826772
• NCBI GeneID: 3483
• NCBI Accession #: NP_004961.1
• NCBI GenBank Nucleotide #: NM_004970.2
• Molecular Weight: 70,236 Da
• NCBI Official Full Name: insulin-like growth factor-binding protein complex acid labile subunit isoform 2
• NCBI Official Synonym Full Names: insulin like growth factor binding protein acid labile subunit
• NCBI Official Symbol: IGFALS
• NCBI Official Synonym Symbols: ALS; ACLSD
• NCBI Protein Information: insulin-like growth factor-binding protein complex acid labile subunit
• UniProt Protein Name: Insulin-like growth factor-binding protein complex acid labile subunit
• Protein Family: Alsin
• UniProt Gene Name: IGFALS
• UniProt Synonym Gene Names: ALS; ALS
• UniProt Entry Name: ALS_HUMAN

NCBI Description

The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Description

IGFALS: Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.

Protein type: Cell adhesion; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: extracellular region; extracellular space; nucleoplasm

Molecular Function: insulin-like growth factor binding

Biological Process: cell adhesion; cellular protein metabolic process; signal transduction

Disease: Acid-labile Subunit Deficiency