Goat Carabin/TBC1D10C Polyclonal Antibody | anti-TBC1D10C antibody
Goat anti-Carabin/TBC1D10C Antibody
Western Blot: Preliminary experiments in Human Tonsil, Thymus and Peripheral Mononucleocytes lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene has an N-terminal Rab-GTPase domain and a binding site at the C-terminus for calcineurin, and is an inhibitor of both the Ras signaling pathway and calcineurin, a phosphatase regulated by calcium and calmodulin. Genes encoding similar proteins are located on chromosomes 16 and 22. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Uniprot Description
TBC1D10C: Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.
Protein type: GAPs, Rab; GAPs
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component: cytosol; endomembrane system; filopodium membrane; intracellular; membrane; plasma membrane
Molecular Function: GTPase activator activity; protein binding; Rab GTPase binding
Biological Process: intracellular protein transport; negative regulation of B cell activation; negative regulation of NFAT protein import into nucleus; regulation of vesicle fusion; retrograde transport, endosome to Golgi
Research Articles on TBC1D10C
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Product Notes
The TBC1D10C tbc1d10c (Catalog #AAA421530) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-Carabin/TBC1D10C Antibody reacts with Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig and may cross-react with other species as described in the data sheet. AAA Biotech's Carabin/TBC1D10C can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Preliminary experiments in Human Tonsil, Thymus and Peripheral Mononucleocytes lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml). Researchers should empirically determine the suitability of the TBC1D10C tbc1d10c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: PRRKPQTRGK TFH. It is sometimes possible for the material contained within the vial of "Carabin/TBC1D10C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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