Goat AKAP6 Polyclonal Antibody | anti-AKAP6 antibody
Goat anti-AKAP6 Antibody
Western Blot: This antibody showed a 190kDa band in lysates of Mouse Heart and of Mouse Parotid (salivary) gland as described by Wu et al, Am J Physiol Cell Physiol.2010 May;298(5): C1151-8. PMID: 20164376.
NCBI and Uniprot Product Information
NCBI Description
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008]
Uniprot Description
AKAP6: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: caveola; cytoplasm; nuclear envelope; nuclear membrane; perinuclear region of cytoplasm; sarcoplasmic reticulum; T-tubule
Molecular Function: adenylate cyclase binding; protein anchor; protein binding; protein complex scaffold; protein kinase A binding
Biological Process: cAMP-mediated signaling; negative regulation of cAMP biosynthetic process; positive regulation of cell growth; positive regulation of NFAT protein import into nucleus; positive regulation of protein phosphatase type 2B activity; positive regulation of release of sequestered calcium ion into cytosol; protein targeting; regulation of action potential
Research Articles on AKAP6
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Product Notes
The AKAP6 akap6 (Catalog #AAA420399) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-AKAP6 Antibody reacts with Tested: Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's AKAP6 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: This antibody showed a 190kDa band in lysates of Mouse Heart and of Mouse Parotid (salivary) gland as described by Wu et al, Am J Physiol Cell Physiol.2010 May;298(5): C1151-8. PMID: 20164376. Researchers should empirically determine the suitability of the AKAP6 akap6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: LTMSVTLSPL RSQ. It is sometimes possible for the material contained within the vial of "AKAP6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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