MET active protein
Recombinant Rat MET (N-GST tag)
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
NCBI and Uniprot Product Information
NCBI Description
hepatocyte growth factor receptor; functions as a heterodimeric tyrosine kinase [RGD, Feb 2006]
Uniprot Description
Met: a proto-oncogenic receptor tyrosine kinase with high affinity for hepatocyte growth factor. The primary single chain precursor protein is post-translationally cleaved to produce the 45 kDa alpha- and 145 kDa beta-subunits, which are disulfide linked to form the mature receptor. Ligand-binding induces autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl and PI3 kinase. Activating point mutations cause hereditary papillary renal carcinoma. Mutations also seen in sporadic renal cell carcinoma and childhood hepatocellular carcinoma. Upregulation in carcinomas and sarcomas correlates with metastasis and poor outcome. Some gastric carcinomas harbor a translocation that creates an activated TPR-Met fusion protein. A small molecule inhibitor (PHA-665752) shows an effect in gastric carcinoma xenografts. Inhibitors: SU11274, PHA-665752, mAbs. Two alternatively spliced human isoforms have been reported.
Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Oncoprotein; Kinase, protein; Protein kinase, TK; TK group; Met family
Cellular Component: extracellular space; neuron projection; cell surface; dendrite; postsynaptic density; integral to membrane; excitatory synapse; postsynaptic membrane; membrane; cell soma; cytoplasm; plasma membrane; basal plasma membrane
Molecular Function: phospholipase binding; protein heterodimerization activity; protein-tyrosine kinase activity; protein complex binding; beta-catenin binding; phosphoinositide 3-kinase binding; hepatocyte growth factor receptor activity; protein phosphatase binding; ATP binding; protein kinase activity
Biological Process: lactation; response to peptide hormone stimulus; muscle development; central nervous system neuron differentiation; peptidyl-tyrosine phosphorylation; activation of MAPK activity; myoblast proliferation; protein amino acid autophosphorylation; neuron migration; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; response to organic cyclic substance; positive chemotaxis; pancreas development; response to wounding; endothelial cell morphogenesis; oligodendrocyte development; placenta development; response to drug; regulation of synaptic transmission; skeletal muscle development; positive regulation of mitosis; male gonad development; myotube differentiation; muscle cell migration; cell aging; hepatocyte growth factor receptor signaling pathway; positive regulation of dendrite morphogenesis; liver development; positive regulation of peptidyl-serine phosphorylation; sperm motility; branching morphogenesis of a tube; adult behavior; positive regulation of transcription from RNA polymerase II promoter; response to acidity; brain development; regulation of excitatory postsynaptic membrane potential; positive regulation of DNA replication
Research Articles on MET
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Product Notes
The MET (Catalog #AAA4160428) is an Active Protein produced from Insect Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MET, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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