Rabbit anti-Human ADAMTS1 Polyclonal Antibody | anti-ADAMTS1 antibody

Anti-ADAMTS1 Antibody

Cat. Num. AAA415769

• Gene Names: ADAMTS1; C3-C5; METH1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified
• Synonyms: ADAMTS1; Polyclonal Antibody; Anti-ADAMTS1 Antibody; Anti-ADAMTS-1 Antibody; anti-ADAMTS1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 967

• Applicable Applications for anti-ADAMTS1 antibody: Peptide ELISA (EIA), Western Blot (WB)
• Application Notes: Recommended dilutions:; Peptide ELISA: 1:160,000; WB: 1:500 - 1:1000; Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
• Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
• Immunogen: Synthetic peptide conjugated to KLH
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Western Blot (WB)

Related Product Information for anti-ADAMTS1 antibody

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.

References

Ng,Y.H., Zhu,H., Pallen,C.J.,et al. Differential effects of interleukin-1beta and transforming growth factor-beta1 on the expression of the inflammation-associatedprotein, ADAMTS-1, in human decidual stromal cells in vitro. Hum. Reprod. 21 (8), 1990-1999 (2006)

NCBI and Uniprot Product Information

• NCBI GI #: 50845384
• NCBI GeneID: 9510
• NCBI Accession #: NP_008919.3
• NCBI GenBank Nucleotide #: NM_006988.4
• Molecular Weight: 105,358 Da
• NCBI Official Full Name: A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein
• NCBI Official Synonym Full Names: ADAM metallopeptidase with thrombospondin type 1 motif, 1
• NCBI Official Symbol: ADAMTS1
• NCBI Official Synonym Symbols: C3-C5; METH1
• NCBI Protein Information: A disintegrin and metalloproteinase with thrombospondin motifs 1; ADAM-TS 1; ADAM-TS1; ADAMTS-1; METH-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1; human metalloproteinase with thrombospondin type 1 motifs
• UniProt Protein Name: A disintegrin and metalloproteinase with thrombospondin motifs 1
• Protein Family: A disintegrin and metalloproteinase with thrombospondin motifs
• UniProt Gene Name: ADAMTS1
• UniProt Entry Name: ATS1_HUMAN

NCBI Description

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]

Uniprot Description

ADAMTS1: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.

Protein type: Protease; Secreted, signal peptide; Motility/polarity/chemotaxis; EC 3.4.24.-; Secreted

Chromosomal Location of Human Ortholog: 21q21.2

Cellular Component: cytoplasm; basement membrane; cytoplasmic vesicle

Molecular Function: heparin binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity

Biological Process: integrin-mediated signaling pathway; negative regulation of cell proliferation; ovulation from ovarian follicle; kidney development; proteolysis