Rabbit anti-Rat Caspr2 (Contactin-Associated Protein 2) Polyclonal Antibody | anti-Caspr2 antibody

Anti-Caspr2 (Contactin-Associated Protein 2) Antibody

Cat. Num. AAA4157647

• Gene Names: CNTNAP2; CDFE; NRXN4; AUTS15; CASPR2; PTHSL1
• Reactivity: Rat
• Applications: Western Blot
• Purity: Affinity Purified On Immobilized Antigen.
• Synonyms: Caspr2 (Contactin-Associated Protein 2); Polyclonal Antibody; Anti-Caspr2 (Contactin-Associated Protein 2) Antibody; anti-Caspr2 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified On Immobilized Antigen.
• Form/Format: Liquid; PBS, pH 7.4 with 0.05% sodium azide.
• Concentration: 1ug/ul (varies by lot)
• Sequence Length: 1331

• Applicable Applications for anti-Caspr2 antibody: Western Blot (WB)
• Immunogen: Peptide (C)DPNF TETID ESKKE WLI, corresponding to amino acid residues 1315-1331 of human Caspr2 (Accession NP_054860)
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.; For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

NCBI and Uniprot Product Information

• NCBI GI #: 7662350
• NCBI GeneID: 26047
• NCBI GenBank Nucleotide #: NP_054860.1
• UniProt Accession #: Q9UHC6
• NCBI Official Full Name: contactin-associated protein-like 2
• NCBI Official Synonym Full Names: contactin associated protein like 2
• NCBI Official Symbol: CNTNAP2
• NCBI Official Synonym Symbols: CDFE; NRXN4; AUTS15; CASPR2; PTHSL1
• NCBI Protein Information: contactin-associated protein-like 2
• UniProt Protein Name: Contactin-associated protein-like 2
• UniProt Gene Name: CNTNAP2

NCBI Description

This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2, a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and intellectual disability. [provided by RefSeq, Jul 2017]

Uniprot Description

Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction.