PINK1 antigen
PINK1
Reactivity
Human
Applications
Western Blot, Immunohistochemistry, ELISA
Purity
Antigen Immunoaffiinity Purification
Synonyms
PINK1; Polyclonal Antigen; PINK1 antigen
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Immunoaffiinity Purification
Form/Format
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Sequence Length
109
Applicable Applications for PINK1 antigen
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Immunogen
Synthetic peptide derived from the human PINK1 protein. Control for antibody to G309D mutant
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Ship at ambient temperature, freeze upon arrival
Ship at ambient temperature, freeze upon arrival
Related Product Information for PINK1 antigen
Description: Synthetic peptide derived from the human PINK1 protein. Control for antibody to G309D mutant.
Background: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
Background: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
Product Categories/Family for PINK1 antigen
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
11,822 Da
NCBI Official Full Name
PINK1
UniProt Protein Name
PINK1
Protein Family
UniProt Gene Name
UNQ740
UniProt Entry Name
Q6UW64_HUMAN
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Product Notes
The PINK1 unq740 (Catalog #AAA396703) is an Antigen produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PINK1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PINK1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). Researchers should empirically determine the suitability of the PINK1 unq740 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PINK1, Polyclonal Antigen" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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