Western Blot/Blotting
(Western blot analysis of TLR9 in mouse spleen cell lysate with TLR9 antibody at (A) 0.5 (B) 1 ug/ml)
Rabbit anti-Human, Mouse Toll-like receptor 9 (TLR9) Polyclonal Antibody | anti-TLR9 antibody
Toll-like receptor 9 (TLR9) (CT)
Western Blot/Blotting
(Western blot analysis of TLR9 in mouse spleen cell lysate with TLR9 antibody at (A) 0.5 (B) 1 ug/ml)
Western Blot/Blotting
(Western blot analysis of TLR9 in mouse spleen cell lysate with TLR9 antibody at (A) 0.5 (B) 1 ug/ml)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. Ref.10 Ref.11
Subunit structure: Interacts with MYD88 via their respective TIR domains
By similarity. Interacts (via transmembrane domain) with UNC93B1
By similarity. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses
By similarity. Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Ref.11 Ref.12
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein
By similarity. Endosome
By similarity. Lysosome
By similarity. Cytoplasmic vesicle › phagosome
By similarity. Note: Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist
By similarity.
Tissue specificity: Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
Sequence similarities: Belongs to the Toll-like receptor family.Contains 26 LRR (leucine-rich) repeats.Contains 1 TIR domain.
Research Articles on TLR9
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Product Notes
The TLR9 tlr9 (Catalog #AAA396039) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Toll-like receptor 9 (TLR9) (CT) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Toll-like receptor 9 (TLR9) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the TLR9 tlr9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Toll-like receptor 9 (TLR9), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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