SDS-Page
(Recombinant METTL11B (NTM1B) protein gel 10% SDS-PAGE Coomassie staining MW: 58.7 kDa Purity: >75%)
METTL11B recombinant protein
Recombinant METTL11B (NTM1B) protein
Gene Names
METTL11B; NTM1B; HOMT1B; C1orf184
Synonyms
METTL11B; Recombinant METTL11B (NTM1B) protein; METTL11B recombinant protein
Host
E Coli
Form/Format
Recombinant METTL11B (NTM1B) protein is supplied in 25mM Tris-HCl pH8.0, 300mM NaCl, 10% glycerol, 0.5mM TCEP.
Protein Species
Human
Tag
GST-Tag
Notes
This product was manufactured as described in Protein Details. Where possible, We has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data for a given product is shown on the lot-specific Technical Data Sheet.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
Shipping Temp: Dry Ice
SDS-Page
(Recombinant METTL11B (NTM1B) protein gel 10% SDS-PAGE Coomassie staining MW: 58.7 kDa Purity: >75%)
SDS-Page
(Recombinant METTL11B (NTM1B) protein gel 10% SDS-PAGE Coomassie staining MW: 58.7 kDa Purity: >75%)
Related Product Information for METTL11B recombinant protein
Short Description: Recombinant METTL11B (NTM1B) protein was expressed in E Coli as the full-length protein (accession number NP_001129579.1) with an N-terminal GST-Tag. The molecular weight of the protein is 58.7 kDa.
Background: METTL11B (Methyltransferase Like 11B, also known as NTM1B or NRMT2), is an alpha-Nmethyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. It specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. METTL11B may activate NTMT1 by priming its substrates for trimethylation.
Background: METTL11B (Methyltransferase Like 11B, also known as NTM1B or NRMT2), is an alpha-Nmethyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. It specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. METTL11B may activate NTMT1 by priming its substrates for trimethylation.
Product Categories/Family for METTL11B recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
32,400 Da
NCBI Official Full Name
alpha N-terminal protein methyltransferase 1B
NCBI Official Synonym Full Names
methyltransferase like 11B
NCBI Official Symbol
METTL11B
NCBI Official Synonym Symbols
NTM1B; HOMT1B; C1orf184
NCBI Protein Information
alpha N-terminal protein methyltransferase 1B; methyltransferase-like protein 11B; X-Pro-Lys N-terminal protein methyltransferase 1B
UniProt Protein Name
Alpha N-terminal protein methyltransferase 1B
Protein Family
UniProt Gene Name
METTL11B
UniProt Synonym Gene Names
C1orf184; NTM1B
UniProt Entry Name
NTM1B_HUMAN
Uniprot Description
Function: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif
By similarity.
Catalytic activity: 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein].2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] = 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein].
Sequence similarities: Belongs to the methyltransferase superfamily. NTM1 family.
Sequence caution: The sequence CAH72139.1 differs from that shown. Reason: Erroneous gene model prediction.
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Product Notes
The METTL11B mettl11b (Catalog #AAA389178) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "METTL11B, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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