Entecavir, Inhibitor

Entecavir

Cat. Num. AAA384694

• Purity: >98%
• Synonyms: Entecavir; ETV; Baraclude; inhibitor

• Purity/Purification: >98%
• Form/Format: Powder
• Concentration: 0.1 mM: 33.86 mL (1 mg); 169.32 mL (5 mg); 338.64mL (10 mg); 0.5 mM: 6.77 mL (1 mg); 33.86 mL (5 mg); 67.73 mL (10 mg); 1 mM: 3.39 mL (1 mg); 16.93 mL (5 mg); 33.86 mL (10 mg); 5 mM: 0.68 mL (1 mg); 3.39 mL (5 mg); 6.77 mL (10 mg) (varies by lot)

• CAS Number: 209216-23-9, 142217-69-4
• Formula: C12H15N5O3.H2O
• SMILES: C=C1[C@@H]([C@H](CC1N2C=NC3=C2NC(=NC3=O)N)O)CO.O
• Actions: Inhibitor
• Solubility (DMSO): 59 mg/mL (199.8 mM)
• Solubility (Ethanol): <1 mg/mL (<1 mM)
• Solubility (Water): <1 mg/mL (<1 mM)
• Availability: We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
• Preparation and Storage: at -20 degree C 3 years Powder

Chemical Structure

Related Product Information for Entecavir, inhibitor

Entecavir is a nucleoside analog (more specifically, a guanosine analogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process. Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection.

References

Kazumoto Murata, .et al. Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection, Gut, 2018, Feb; 67(2): 362-371 PMID: 27789659
Jianfei L, .et al. The Ca2+/CaMKK2 axis mediates the telbivudine induced upregulation of creatine kinase: Implications for mechanism of antiviral nucleoside analogs' side effect, Biochem Pharmacol, 2017, Dec 15;146:224-232 PMID: 29038020