Mouse anti-Human CD41 Monoclonal Antibody | anti-CD41 antibody
Mouse anti CD41 [M148]
Reactivity
Human
Applications
Flow Cytometry, Functional Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation
Purity
Purified on protein A from tissue culture supernatant.
Synonyms
CD41; Monoclonal Antibody; Mouse anti CD41 [M148]; CD41B; GP2B; GPalpha IIb; GPIIb; GTA; HPA3; integrin alpha 2b; Integrin alpha-IIb; Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain; form 1; form 2; integrin; alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex; antigen CD41); ITA2B; ITGA2B; ITGAB; platelet fibrinogen receptor; alpha subunit; Platelet membrane glycoprotein IIb; platelet-specific antigen BAK; anti-CD41 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
M148
Specificity
This antibody recognises integrin alpha 2b, a 110-130 kDa transmembrane protein that is also known as CD41. CD41 associates with the integrin CD61 to form the CD41/CD61 (GPIIb/IIIa) heterodimer, a fibronectin receptor expressed in platelets. The antibody M148 binds to some medulloblastoma and neuroblastoma cells and rhabdomyosarcoma and certain other solid tumours. No binding is observed to marrow constituents other than platelets and megakaryocytes. The antibody M148 prevents aggregation of platelets.
Purity/Purification
Purified on protein A from tissue culture supernatant.
Form/Format
Purified IgG supplied in Phosphate buffered saline (PBS) containing 0.09% Sodium azide
Concentration
1mg/ml (varies by lot)
Sequence Length
185
Applicable Applications for anti-CD41 antibody
Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin, Immunoprecipitation (IP)
Application Notes
Optimal antibody dilution should be determined by titration
Target Antigen
CD41
Immunogen
Homogenized human medulloblastoma tissue.
Myeloma/fusion Partners
Cells from immunized Balb/c mice were fused with the P3X63Ag8.653 myeloma cell line
Research Areas
Cell adhesion; Immune response
References
Jones D, et al. A monoclonal antibody binding to human medulloblastoma cells and to the platelet glycoprotein IIB-IIIA complex. Br J Haematol. 1984.57(4):621-31. PMID:6234927 http://www.ncbi.nlm.nih.gov/pubmed/6234927
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
20,050 Da
NCBI Official Full Name
CD41 antigen, partial
UniProt Protein Name
CD41 antigen
UniProt Gene Name
CD41
UniProt Entry Name
F7J059_TURTR
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Product Notes
The CD41 cd41 (Catalog #AAA375283) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse anti CD41 [M148] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD41 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin, Immunoprecipitation (IP). Optimal antibody dilution should be determined by titration. Researchers should empirically determine the suitability of the CD41 cd41 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD41, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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