Dilution Information
Rabbit anti-Human NKX3.1 Monoclonal Antibody | anti-NKX3.1 antibody
NKX3.1 (RM430)
Reactivity
Human
Synonyms
NKX3.1; Monoclonal Antibody; NKX3.1 (RM430); NKX3A; sc393190; Nkx 3.1; Nkx3.1; NKX3-1; anti-Nkx-3.1; anti Nkx-3.1; anti-Nkx 3.1; anti-Nkx3.1; anti Nkx 3.1; anti Nkx3.1; Homeobox protein NK-3 homolog A; anti-NKX3A; anti NKX3A; anti-Homeobox protein NK-3 homolog A; anti Homeobox protein NK-3 homolog A; NK3 homeobox 1; BAPX2; NKX3; NKX3 1; anti-NKX3.1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
RM430
Form/Format
Paraffin, Frozen
NKX3.1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
NKX3.1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
A synthetic peptide corresponding to residues of human NKX3.1 protein.
Control
Prostate, Prostate Carcinoma
Localization
Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(NKX3.1 Antibody Immunohistochemistry on an FFPE Prostatic Carcinoma Tissue)
Immunohistochemistry (IHC)
(NKX3.1 Antibody Immunohistochemistry on an FFPE Prostatic Carcinoma Tissue)
Related Product Information for anti-NKX3.1 antibody
Homeobox protein NKX3.1, also known as BAPX2 and NKX3A is a protein that in humans is encoded by the NKX3.1 gene located on chromosome 8p. NKX3.1 is a prostatic tumor suppressor gene, which is an androgen-regulated, prostate-specific homeobox gene whose expression is predominantly localized in the prostate epithelium. It is a negative regulator of epithelial cell growth in prostate tissue. Loss of NKX3A protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia. NKX3-1 expression is seen in prostate epithelium, testis, ureter, and pulmonary bronchial mucous glands.
NKX3-1 antibody has been established as a marker for identifying metastatic tumors. In a study the sensitivity for identifying metastatic prostatic adenocarcinomas was 98.6% for NKX3.1, 94.2% for prostate specific antigen and 98.6% for prostatic acid phosphatase and a specificity of 99.7% for NKX3.1. NKX3.1-positive prostate carcinoma cells exhibit nuclear staining. Additionally, most cases of urothelial carcinoma have been found to be negative for NKX3.1 and may be helpful to distinguish between high grade prostate adenocarcinoma and high grade Infiltrating urothelial carcinoma. NKX3.1 antibody has also been found to be expressed in invasive ductal carcinomas (IDC) and invasive lobular carcinomas (ILC) of the breast. NKX3.1 expression is limited to ER, PR, and AR positive carcinomas and is more frequently expressed in ILC than IDC. NKX3.1 has a high specificity and sensitivity for prostate adenocarcinomas and can be used to help distinguish between prostate carcinoma and urothelial carcinomas.
NKX3-1 antibody has been established as a marker for identifying metastatic tumors. In a study the sensitivity for identifying metastatic prostatic adenocarcinomas was 98.6% for NKX3.1, 94.2% for prostate specific antigen and 98.6% for prostatic acid phosphatase and a specificity of 99.7% for NKX3.1. NKX3.1-positive prostate carcinoma cells exhibit nuclear staining. Additionally, most cases of urothelial carcinoma have been found to be negative for NKX3.1 and may be helpful to distinguish between high grade prostate adenocarcinoma and high grade Infiltrating urothelial carcinoma. NKX3.1 antibody has also been found to be expressed in invasive ductal carcinomas (IDC) and invasive lobular carcinomas (ILC) of the breast. NKX3.1 expression is limited to ER, PR, and AR positive carcinomas and is more frequently expressed in ILC than IDC. NKX3.1 has a high specificity and sensitivity for prostate adenocarcinomas and can be used to help distinguish between prostate carcinoma and urothelial carcinomas.
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Product Notes
The NKX3.1 (Catalog #AAA370550) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NKX3.1 (RM430) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "NKX3.1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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