Structure
SB-743921, Inhibitor
SB-743921
Purity
>98% (HPLC)
Synonyms
SB-743921; SB743921; SB 743921; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Kinesin
Receptor
KSP; KSP (Colo205cells); KSP (MV522cells); KSP (MX1cells); KSP (SKOV3cells)
Chemical Name
Benzamide, N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methyl-, hydrochloride(1:1)
SMILES
CC1=CC=C(C=C1)C(=O)N(CCCN)C(C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl
Molecular Formula
C31H34Cl2N2O3
CAS Number
940929-33-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SB-743921, inhibitor
SB-743921 is a potent, selective kinesin spindle protein (KSP) inhibitor with Ki of 0.1nM, shows no activity against MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E; also shows high affinity for mouse KSP with Ki of 0.12nM; blocks assembly of a functional mitotic spindle, thereby causing cell cycle arrest in mitosis and subsequent cell death in cancer cells, demonstrates improved potency over ispinesib in both biochemical and cellular assays; shows a broad spectrum of tumor inhibition in multiple cancer models. Blood Cancer Phase 2 Discontinued
Product Categories/Family for SB-743921, inhibitor
References
1. Good JA, et al. J Med Chem. 2013 Mar 14; 56 (5):1878-93.
2. Holen KD, et al. Cancer Chemother Pharmacol. 2011 Feb; 67 (2):447-54.
3. Zhu L, et al. Anticancer Drugs. 2016 Oct; 27 (9):863-72.
4. Talapatra SK, et al. J Med Chem. 2013 Aug 22; 56 (16):6317-29.
2. Holen KD, et al. Cancer Chemother Pharmacol. 2011 Feb; 67 (2):447-54.
3. Zhu L, et al. Anticancer Drugs. 2016 Oct; 27 (9):863-72.
4. Talapatra SK, et al. J Med Chem. 2013 Aug 22; 56 (16):6317-29.
Similar Products
Product Notes
The SB-743921 (Catalog #AAA3606725) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SB-743921, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
