Structure
MK-0354 Biochemical
MK-0354
Purity
>98% (HPLC)
Synonyms
MK-0354; MK0354; MK-0354 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=36mg/mL
Target
GPR119
Receptor
GPR119
Chemical Name
Cyclopentapyrazole, 1, 4, 5, 6-tetrahydro-3-(2H-tetrazol-5-yl)
SMILES
C12=C(CCC2)C(C3=NN=NN3)=NN1
Molecular Formula
C7H8N6
CAS Number
851776-28-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MK-0354 biochemical
MK-0354 is a potent, selective niacin receptor GPR109A partial agonist with EC50 of 1.65 and 1.08uM for hGPR109A andmgPR109A in the whole cell cAMP assays; shows no interaction with any other target in a panel of over 120 other proteins; MK-0354 is a competitive inhibitor of 3H-nicotinic acid binding to hGPR109a with Ki of 505nM, fully inhibits isoproterenol stimulated lipolysis in human adipocytes with IC50 of 3.1uM, also is a competitive antagonist of nicotinic acid-induced MAPK signaling in cells overexpressing eithermgPR109a or hGPR109a; possesses plasma FFA lowering effects in mice comparable to those of nicotinic acid, does not induce vasodilation. Atherosclerosis Phase 2 Discontinued
Product Categories/Family for MK-0354 biochemical
References
1. Semple G, et al. J Med Chem. 2008 Aug 28; 51 (16):5101-8.
2. Lai E, et al. J Clin Lipidol. 2008 Oct; 2 (5):375-83.
3. Walters RW, et al. J Clin Invest. 2009 May; 119 (5):1312-21.
4. Gaidarov I, et al. Cell Signal. 2013 Oct; 25 (10):2003-16.
2. Lai E, et al. J Clin Lipidol. 2008 Oct; 2 (5):375-83.
3. Walters RW, et al. J Clin Invest. 2009 May; 119 (5):1312-21.
4. Gaidarov I, et al. Cell Signal. 2013 Oct; 25 (10):2003-16.
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Product Notes
The MK-0354 (Catalog #AAA3606187) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MK-0354, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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