Structure
Nebicapone, Inhibitor
Nebicapone
Purity
>98% (HPLC)
Synonyms
Nebicapone; BIA 3-202; BIA3-202; inhibitor
Purity/Purification
>98% (HPLC)
Target
COMT
Receptor
COMT
Chemical Name
1-(3, 4-dihydroxy-5-nitrophenyl)-2-phenylethan-1-one
SMILES
O=[N+](C1=C(O)C(O)=CC(C(CC2=CC=CC=C2)=O)=C1)[O-]
Molecular Formula
C14H11NO5
CAS Number
274925-86-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Nebicapone, inhibitor
Nebicapone (BIA 3-202, BIA3-202) is a potent, long-acting, reversible and competitive peripheral inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 3.7nM for rat brain COMT, much less potent for liver COMT with IC50 of 696nM; enhances the availability of L-DOPA to the brain and reduces its O-methylation, Nebicapone (BIA 3-202, BIA3-202) is an adjunct to levodopa/carbidopa or levodopa/benserazide in the treatment of Parkinson's disease. Parkinson Disease Phase 1 Discontinued
Product Categories/Family for Nebicapone, inhibitor
References
1. Parada A, et al. Pharmacology. 2003 May; 68 (1):29-37.
2. Bonifacio MJ, et al. Eur J Pharmacol. 2003 Jan 24; 460 (2-3):163-70.
3. Learmonth DA, et al. J Med Chem. 2002 Jan 31; 45 (3):685-95.
4. Parada A, et al. Eur J Pharmacol. 2001 May 18; 420 (1):27-32.
2. Bonifacio MJ, et al. Eur J Pharmacol. 2003 Jan 24; 460 (2-3):163-70.
3. Learmonth DA, et al. J Med Chem. 2002 Jan 31; 45 (3):685-95.
4. Parada A, et al. Eur J Pharmacol. 2001 May 18; 420 (1):27-32.
Similar Products
Product Notes
The Nebicapone (Catalog #AAA3603841) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Nebicapone, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
