Structure
eFT508 Biochemical
eFT508
Purity
>98% (HPLC)
Synonyms
eFT508; eFT 508; Tomivosertib; eFT508 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 6mg/mL (Need ultrasonic)
Target
MNK
Receptor
MNK1; MNK2
Chemical Name
Spiro[cyclohexane-1, 3'(2'H)-imidazo[1, 5-a]pyridine]-1', 5'-dione, 6'-[(6-amino-4-pyrimidinyl)amino]-8'-methyl
SMILES
CC1=C2C(=O)NC3(N2C(=O)C(=C1)NC4=NC=NC(=C4)N)CCCCC3
Molecular Formula
C17H20N6O2
CAS Number
1849590-01-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for eFT508 biochemical
eFT508 (Tomivosertib) is apotent, highly selective, reversible, ATP-competitive, and orally bioavailable MNK1 and MNK2 inhibitor with IC50 of 1-2nM in enzyme assays; dose-dependently reduces eIF4E phosphorylation at Serine 209 in tumor cell lines with IC50 of 2-16nM; shows anti-proliferative activity against multiple DLBCL cell lines, decreases the production of pro-inflammatory cytokines including TNFalpha, IL-6, IL-10 and CXCL10; demonstrates significant anti-tumor activity in human lymphoma xenograft models which harbor activating MyD88 mutations. Blood Cancer Phase 2 Clinical
Product Categories/Family for eFT508 biochemical
References
1. Kevin R. Webster, et al. Blood 2015 126:1554;
2. Dreas A, et al. Curr Med Chem. 2017; 24 (28):3025-3053.
2. Dreas A, et al. Curr Med Chem. 2017; 24 (28):3025-3053.
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Product Notes
The eFT508 (Catalog #AAA3602857) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "eFT508, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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