Structure
Semapimod hydrochloride, Inhibitor
Semapimod hydrochloride
Purity
>98% (HPLC)
Synonyms
Semapimod hydrochloride; CNI 1493; AXD-455; inhibitor
Purity/Purification
>98% (HPLC)
Target
TLR
Receptor
TLR
Chemical Name
N1, N10-bis(3-(1-(2-carbamimidoylhydrazono)ethyl)-5-(1-(2-carbamimidoylhydrazono)ethyl)phenyl)decanediamide tetrahydrochloride
SMILES
CC(=NN=C(N)N)C1=CC(=CC(=C1)NC(=O)CCCCCCCCC(=O)NC2=CC(=CC(=C2)C(=NN=C(N)N)C)C(=NN=C(N)N)C)C(=NN=C(N)N)C.Cl.Cl.Cl.Cl
Molecular Formula
C34H56Cl4N18O2
CAS Number
164301-51-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Semapimod hydrochloride, inhibitor
Semapimod (CNI 1493; AXD-455) is a tetravalent guanylhydrazone that acts as a selective inhibitor of cytokine-inducible arginine transport and NO production, inhibits TLR4 signaling (IC50=0.3uM) by targeting the TLR chaperone gp96; does not inhibit EDRF activity, inhibits nitric oxide synthesis by inflammatory macrophages; prevents the development of carrageenan-induced footpad inflammation, and conferred protection against lethal LPS challenge in mice. Irritable Bowel Syndrome Phase 2 Clinical
Product Categories/Family for Semapimod hydrochloride, inhibitor
References
1. Bianchi M, et al. Mol Med. 1995 Mar; 1 (3):254-66.
2. Bianchi M, et al. J Exp Med. 1996 Mar 1; 183 (3):927-36.
3. Cohen PS, et al. Proc Natl Acad Sci U S A. 1996 Apr 30; 93 (9):3967-71.
2. Bianchi M, et al. J Exp Med. 1996 Mar 1; 183 (3):927-36.
3. Cohen PS, et al. Proc Natl Acad Sci U S A. 1996 Apr 30; 93 (9):3967-71.
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Product Notes
The Semapimod hydrochloride (Catalog #AAA3602498) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Semapimod hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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