Structure
BAY 1251152, Inhibitor
BAY 1251152
Purity
>98% (HPLC)
Synonyms
BAY 1251152; (+)-BAY 1251152; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 113.3mg/mL (280.15mM)
Target
CDK
Receptor
CDK
Chemical Name
(+)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl]pyridin-2-amine
SMILES
N=S(CC1=CC(NC2=NC=C(F)C(C3=CC=C(F)C=C3OC)=C2)=NC=C1)(C)=O
Molecular Formula
C19H18F2N4O2S
CAS Number
1610358-56-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BAY 1251152, inhibitor
BAY 1251152 is the first potent, selective, orally available PTEFb/CDK9 inhibitor with biochemical IC50 of 9nM and MOLM13 cell IC50 of 29nM, displays>50-fold selectivity against other CDKs; exhibits broad anti-proliferative activity against a panel of tumour cell lines with sub-micromolar IC50 values; demonstrates excellent efficacy in xenograft models (e. G. MOLM13) in mice and rats. Blood Cancer Phase 1 Clinical
Product Categories/Family for BAY 1251152, inhibitor
References
1. Ulrich T. Luecking, et al. Abstract 984: Identification of potent and highly selective PTEFb inhibitor BAY 1251152 for the treatment of cancer: from p.o. to i.v. application via scaffold hops. DOI: 10.1158/1538-7445.
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Product Notes
The BAY 1251152 (Catalog #AAA3602323) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BAY 1251152, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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