Structure
CC-401 hydrochloride, Inhibitor
CC-401 hydrochloride
Purity
>98% (HPLC)
Synonyms
CC-401 hydrochloride; CC 401 hydrochloride; CC401 hydrochloride; CC401 HCl; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
JNK
Receptor
JNK
Chemical Name
1H-Indazole, 3-[3-[2-(1-piperidinyl)ethoxy]phenyl]-5-(1H-1, 2, 4-triazol-5-yl)-, hydrochloride(1:1)
SMILES
C1CCN(CC1)CCOC2=CC=CC(=C2)C3=NNC4=C3C=C(C=C4)C5=NC=NN5.Cl
Molecular Formula
C22H25ClN6O
CAS Number
1438391-30-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for CC-401 hydrochloride, inhibitor
CC-401 hydrochloride is a potent, selective, ATP-competitive pan-JNK inhibitor with Ki of 25-50nM, displays >40-fold selectivity over other related kinases, including p38, ERK, IKK2, PK C, Lck, and ZAP70; decreases hepatic necrosis and apoptosis after orthotopic liver transplantation in vivo; blocks JNK signaling in the rat obstructed kidney and significantly inhibits renal fibrosis in terms of interstitial myofibroblast accumulation and collagen IV deposition, also significantly reduces tubular apoptosis in the obstructed kidney; sensitizes hypoxic colon cancer cells to DNA-damaging agents, potentiates the effect of bevacizumab and oxaliplatin in HT29-derived mouse xenografts. Blood CancervPhase 1 Discontinued
Product Categories/Family for CC-401 hydrochloride, inhibitor
References
1. Uehara T, et al. Transplantation. 2004 Aug 15; 78 (3):324-32.
2. Uehara T, et al. J Hepatol. 2005 Jun; 42 (6):850-9.
3. Ma FY, et al. J Am Soc Nephrol. 2007 Feb; 18 (2):472-84.
4. Vasilevskaya IA, et al. Clin Cancer Res. 2015 Sep 15; 21 (18):4143-52.
2. Uehara T, et al. J Hepatol. 2005 Jun; 42 (6):850-9.
3. Ma FY, et al. J Am Soc Nephrol. 2007 Feb; 18 (2):472-84.
4. Vasilevskaya IA, et al. Clin Cancer Res. 2015 Sep 15; 21 (18):4143-52.
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Product Notes
The CC-401 hydrochloride (Catalog #AAA3601859) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CC-401 hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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