Mouse Human Immunodeficiency Virus Type 1, HIV-1 p24 Monoclonal Antibody | anti-HIV-1 antibody
Human Immunodeficiency Virus Type 1, HIV-1 p24 mAb (Mouse anti-human, clone # E12)-Detection Ab
Reactivity
Human
Applications
ELISA
Purity
>95% by HPLC & SDS-PAGEProtein A or G purified and supplied in 0.9% NaCl without preservative
Synonyms
Human Immunodeficiency Virus Type 1; HIV-1 p24; Monoclonal Antibody; HIV-1 p24 mAb (Mouse anti-human; clone # E12)-Detection Ab; Monoclonal Anti-HIV-1 p24 (Detection Ab); anti-HIV-1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
E12
Purity/Purification
>95% by HPLC & SDS-PAGE
Protein A or G purified and supplied in 0.9% NaCl without preservative
Protein A or G purified and supplied in 0.9% NaCl without preservative
Form/Format
Liquid
Applicable Applications for anti-HIV-1 antibody
ELISA (EIA)
Immunogen
Recombinant human HIV-1 p24 Protein (Expression system with E Coli).
Preparation and Storage
Aliquot and store at -20 degree C for long term (at least for one year). Avoid repeated freeze and thaw cycles.
Related Product Information for anti-HIV-1 antibody
Acquired immune deficiency syndrome (HIV/AIDS) has been a major global health concern for over 38 years. No safe and effective preventive or therapeutic vaccine has been developed although many products have been investigated. Computational methods have facilitated vaccine developments in recent decades. Among HIV-1 proteins, p24 and Nef are two suitable targets to provoke the cellular immune response. The predicted fusion protein, p24-AAY-Nef in a truncated form with a high rate of T cell epitopes and high conservancy rate among different clades, provides a helpful model for developing a therapeutic vaccine candidate against HIV-1. HIV-1 infection of macrophages leads to the sequestration of newly formed viruses in intracellular plasma membrane-connected structures termed virus-containing compartments (VCCs), where virions remain infectious and hidden from immune surveillance. HIV-1 infection of macrophages leads to the sequestration of newly formed viruses in virus-containing compartments (VCCs), where virions remain infectious and hidden from immune surveillance. The transmembrane domain of Vpu and two motifs of the Vpu cytoplasmic domain are required for these functions. These motifs were notably involved in the control of the volume of VCCs by Vpu but were dispensable for the prevention of the specific accumulation of BST2 in these structures.
Product Categories/Family for anti-HIV-1 antibody
References
1. Larijani MS, Sadat SM, Bolhassani A, Pouriayevali MH, Bahramali G, Ramezani A. In Silico Design and Immunologic Evaluation of HIV-1 p24-Nef Fusion Protein to Approach a Therapeutic Vaccine Candidate. Curr HIV Res. 2018;16(5):322-337.
2. Leymarie O, Lepont L, Versapuech M, Judith D, Abelanet S, Janvier K, Berlioz-Torrent C. Contribution of the Cytoplasmic Determinants of Vpu to the Expansion of Virus-Containing Compartments in HIV-1-Infected Macrophages. J Virol. 2019 May 15;93(11).
2. Leymarie O, Lepont L, Versapuech M, Judith D, Abelanet S, Janvier K, Berlioz-Torrent C. Contribution of the Cytoplasmic Determinants of Vpu to the Expansion of Virus-Containing Compartments in HIV-1-Infected Macrophages. J Virol. 2019 May 15;93(11).
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Product Notes
The HIV-1 (Catalog #AAA355925) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Human Immunodeficiency Virus Type 1, HIV-1 p24 mAb (Mouse anti-human, clone # E12)-Detection Ab reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Human Immunodeficiency Virus Type 1, HIV-1 p24 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the HIV-1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Human Immunodeficiency Virus Type 1, HIV-1 p24, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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